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Clinical assessment of trough levels for monitoring of rejection in cyclosporine-treated kidney transplant recipients

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Abstract

We evaluated whether trough cyclosporine (CYA) level monitoring was useful in the diagnosis of rejection within 2 weeks after transplantation. Rejection occurred in 14 out of 17 patients (82.3%) treated with CYA, mizoribine (MZR) and prednisolone (Pred) when trough CYA levels dropped below 70 ng/ml, suggesting the importance of trough level monitoring. When anti-lymphocyte globulin (ALG) was added to the 3 above-mentioned drugs, however, rejection occurred in only 1 patient (6.7%) and 2 patients (13.3%), respectively, within 1 week and 1–2 weeks after transplantation, suggesting that through level monitoring isless important in patients treated with these 4 drugs.

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References

  1. Calne, R. Y., White, D. J. G., Thiru, S.: Cyclosporine A in patients receiving renal allografts from cadaver donors.Lancet, 2, 1323 (1978).

    Article  PubMed  CAS  Google Scholar 

  2. Gravel J., Napoli, K. L., Gibbons, S.: Area under the curve monitoring of cyclosporine therapy: Performance of different, assay methods and their target concentration.Ther. Drug Monit., 12, 8 (1991).

    Article  Google Scholar 

  3. Japanese FK506 study group. Japanese study of FK506 on kidney transplantation: The benefit of monitoring the whole blood FK506 concentration, an early phase II study.Transplant. Proc., 23, 3085 (1991).

    Google Scholar 

  4. Takahara, S., Fukunishi, T., Kokado, Y., Ichikawa, Y., Ishibashi, M., Nagano, S., Sonoda, T.: Combined immunosuppression with low dose cyclosporine, mizoribine and prednisolone.Transplant. Proc., 20, 147 (1988).

    PubMed  CAS  Google Scholar 

  5. Kodako, Y., Ishibashi, M., Jiang, H., Takahara, S., Sonoda, T.: A new triple-drug therapy.Clin. Transplant., 4, 191 (1990).

    Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Osaka University Medical School, Osaka, Japan

    S. Takahara, M. Namiki, Y. Kokado, H. Kameoka & A. Okuyama

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  1. S. Takahara
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  2. M. Namiki
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  3. Y. Kokado
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  4. H. Kameoka
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  5. A. Okuyama
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Takahara, S., Namiki, M., Kokado, Y. et al. Clinical assessment of trough levels for monitoring of rejection in cyclosporine-treated kidney transplant recipients. International Urology and Nephrology 28, 431–438 (1996). https://doi.org/10.1007/BF02550507

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  • DOI: https://doi.org/10.1007/BF02550507

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