Abstract
Responsiveness to recall antigens was studied by the use of Multitest-Merieux in 20 cases of kidney tumour with and without deposits. The patients of either group, compared with the controls, had depressed scores of immunoreactivity. After surgical removal of the tumour-bearing kidney, immunoreactivity increased, regardless of the presence or absence of deposits. The number of reacting antigens also increased in every case. Lymphocyte transformationin vitro was also depressed, in comparison with the controls before surgery, but after the intervention the transformed blast cells increased in number. Multitest was found suitable for studies of delayed-type sensitivity.
Similar content being viewed by others
References
Brosman, S., Hausman, M., Shaks, S. J.: Studies on the immune status of patients with adenocarcinoma.J. Urol., 114, 375 (1975).
Brosman, S., Elhilali, M., Vescera, C., Fahey, I.: Immune response in bladder cancer patients.J. Urol., 121, 162 (1979).
Catalona, W. J., Ratliff, T. L., McCool, R.: Concanavalin A inducible suppressor cells in regional lymph nodes of cancer patients.Cancer Res., 39, 372 (1979).
Delbrück, H., Schwarze, G., Kopper, B.: Immunmonitorung mit Recell-Antigenen bei Patienten mit disseminiertem malignem Hodenteratom.Beitr. Onkol., 8, 271 (1981).
Dunzendorfer, U., Jung, K., Ohlenschläger, G.: Transferrin, C3 complement, haptoglobin, plasminogen and alfa-2-macroglobulin in patients with urogenital tumors.Eur. Urol., 6, 232 (1980).
Flamm, J., Sagaster, P., Miksche, M.: Klinische und immunologische Untersuchungen bei Patienten mit Harnblasentumoren.Urologe, 17, 111 (1978).
Hakala, T. R., Lange, P. H., Castro, A., Ellio, A., Fraley, E. E.: Cell-mediated cytotoxicity against human transitional cell carcinoma of the genitourinary tract.Cancer, 34, 1929 (1974).
Hellström, J., Hellström, K. E., Sjögren, H. O., Warner, G. A.: Demonstration of cell-mediated immunity to human neoplasms of various histological types.Int. J. Cancer, 7, 1 (1971).
Jonian, M., Baert, T.: Evaluation of beta-2-microglobulin as a marker for malignancy in cystic fluids, especially in renal origin. Extract from Symp. on beta-2-microglobulin in proliferative disorders.Bruxelles Abstr., 3 (1977).
Kulcsár, G., Dán, P., Sallay, K., Nász, I.: Human lymphocyte transformation studies with viral antigens.Kísérl. Orvostud., 24, 69 (1972).
Lachaud, A. T., Martin-Mondiers, C.: Immune evaluation with skin test in prostatic carcinoma.Eur. Urol., 5, 117 (1979).
Martinez-Pineiro, J. A., Muntanola, P., Hidalgo, L.: Immunological evaluation in patients with urological cancer.Eur. Urol., 3, 109 (1977).
Romics, I.: Immunological aspects of urinary-tract tumours (in Hung.).Orvosképzés, 60, 45 (1985).
Romics, I.: Diagnostic and therapeutic possibilities based on the immune status of patients with tumours of bladder and prostate. Candidate's Thesis, Budapest 1985.
Romics, I., Horváth, J.: Study of nonspecific lymphocyte transformation in urologic cancer patients.Int. Urol. Nephrol., 10, 261 (1978).
Romics, I., Horváth, J., Fehér, J., Csontai, Á.: Effect of levamisol on cellular and humoral immunoreactivity and recurrences in patients with bladder papilloma.Int. Urol. Nephrol., 17, 323 (1985).
Sharding, B., Mayer, W., Schwarze, G., Delbrück, H.: Delayed type skin testing in patients with benign and malignant urogenital tumors. A two-year follow-up in 143 patients. Abstr. 16. Dtsch. Krebskongress, München 1982.
Schwarze, G.: Evaluation of cell-mediated immunity in renal cancer patients: influence of tumor nephrectomy and immunotherapy. I. Internat. Multitest Workshop, Lyon 1983.
Stefani, S. S., Menon, M., Canning, I. R., Clark, S. S.: Cell-mediated immunity in carcinoma of the prostate.Invest. Urol., 14, 72 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Romics, I., Répássy, D., Kulcsár, G. et al. Immune studies by the use of Multitest-Merieux in patients with kidney tumours. International Urology and Nephrology 19, 115–121 (1987). https://doi.org/10.1007/BF02550460
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02550460