Skip to main content
SpringerLink
Log in

Prostatic acid phosphatase and prostate specific antigen in liver disease

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Serum concentrations of prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) were measured in 51 liver cirrhosis, 37 chronic active hepatitis (CAH) patients and 26 healthy individuals. Elevated PSA levels have been found in 2 of cirrhotic patients while no increase has been detected in CAH and controls. Serum PAP levels have been observed slightly increased in 2 patients with cirrhosis, 2 patients with CAH and 1 control case. Mean PSA and mean PAP values showed no significant difference between groups (p>0.05). Serum PSA and PAP levels are reliable in diagnosing and monitoring prostate cancer in chronic liver patients and maintain their specificity in this situation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Schwartz, M. K.: Cancer markers. In: Cancer, Principles and Practice of Oncology. J. B. Lippincott, Philadelphia 1993.

    Google Scholar 

  2. Akdas, A., Şimşek, F., Ilker, Y., Türkeri, L., Ercan, H.: The value of prostatic acid phosphatase and prostate specific antigen as serum markers in carcinoma of the prostate.Int. Urol. Nephrol., 25, 271 (1993).

    PubMed  CAS  Google Scholar 

  3. Minton, J. P., Chewinsky, A.: Present status of serum markers.Sem. Surg. Oncol., 5, 426 (1989).

    CAS  Google Scholar 

  4. Jacops, E. L., Haskell, C. M.: Clinical use of tumor markers in oncology.Curr. Prob. Cancer, 6, 301 (1991).

    Article  Google Scholar 

  5. Kadayifci, A., Ozyilkan, E., Şimşek, H., Sivri, B., Kayhan, B., Ozkuyumcu, C., Telatar, H.: The elevation of serum tumor markers CA 19-9 and CA 125 in chronic liver disease type B and C.Eur. J. Cancer, 29A (Suppl. 6), 245 (1993)

    Article  Google Scholar 

  6. Henneberry, M. D., Engel, G., Grayhack, J. T.: Acid phosphatase.Urol. Clin. North Am., 6, 629 (1979).

    PubMed  CAS  Google Scholar 

  7. DiPaolo, C. J., Rival, J.: Acid phosphatase: Clinical utility of the first tumor marker.Henry Ford Hosp. Med. J., 30, 70 (1982).

    PubMed  CAS  Google Scholar 

  8. Heller, J. E.: Prostatic acid phosphatase: Its current clinical status.J. Urol., 137, 1091 (1987).

    PubMed  CAS  Google Scholar 

  9. Tavassoli, M., Rizo, M., Yam, L. T.: Elevation of serum acid phosphatase in cancers with bone metastasis.Cancer, 45, 2400 (1980).

    Article  PubMed  CAS  Google Scholar 

  10. Cooper, J. F.: The radioimmunochemical measurement of prostatic acid phosphatase: Current state of the art.Urol. Clin. North. Am., 7, 653 (1980).

    PubMed  CAS  Google Scholar 

  11. Ruckle, H. C., Klee, G. G., Oesterling, J. E.: Prostate specific antigen: Critical issues for practising physicians.Mayo Clin. Proc., 69, 59 (1994).

    PubMed  CAS  Google Scholar 

  12. Ashwell, G., Morell, A. G.: The role of surface carbohydrates in the hepatic recognition and transport of circulating glicoproteins.Adv. Enz. Relat. Areas Mol. Biol. 41, 99 (1974).

    CAS  Google Scholar 

  13. Putzki, H., Ledwoch, J.: Tumor markers CEA, TPA, and CA 19-9 in liver diseases.J. Surg. Oncol., 37, 133 (1987).

    Google Scholar 

  14. Virji, M. A., Mercer, D. W., Herberman, R.: New immunologic markers for monitoring of cancer.Ann. Chir. Gynaecol., 78, 13 (1989).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Hacettepe University Medical School, Ankara, Turkey

    A. Kadayifci, M. Benekli, H. Şimşek & O. Sencan

Authors
  1. A. Kadayifci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Benekli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Şimşek
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. Sencan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kadayifci, A., Benekli, M., Şimşek, H. et al. Prostatic acid phosphatase and prostate specific antigen in liver disease. International Urology and Nephrology 28, 67–71 (1996). https://doi.org/10.1007/BF02550140

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02550140

Keywords

Search

Navigation