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Interferon α therapy for chronic active hepatitis type C after renal transplantation and allograft rejection

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Abstract

An acute type rejection episode occurred in one of two patients treated with Interferon α (IFN α) for type C hepatitis (CHC).

Histopathological examination of the graft kidney revealed focal cellular infiltration and chronic transplant glomerulopathy which showed acute or chronic type rejection.

In spite of bolus administration of methyl-prednisolone, the elevation of serum creatinine level continued. After administration of anti-human lymphocyte globulin (AHLG), renal function improved, but urinary protein was still positive.

Another patient had no episode of rejection during or after IFN α therapy.

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Authors and Affiliations

  1. Department of Urology, Osaka University Medical School, Japan

    S. Takahara, K. Kakimoto, Y. Kokado, H. Kameoka, M. Ishibashi & A. Okuyama

  2. Second Department of Internal Medicine, Osaka University Medical School, Japan

    S. Kawada

  3. Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Japan

    M. Kyo & O. Mikami

  4. Department of Urology, Kannsai Medical University, Japan

    S. Nagano

Authors
  1. S. Takahara
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  2. K. Kakimoto
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  3. Y. Kokado
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  4. H. Kameoka
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  5. M. Ishibashi
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  6. S. Kawada
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  7. M. Kyo
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  8. S. Nagano
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  9. O. Mikami
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  10. A. Okuyama
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Takahara, S., Kakimoto, K., Kokado, Y. et al. Interferon α therapy for chronic active hepatitis type C after renal transplantation and allograft rejection. International Urology and Nephrology 27, 479–485 (1995). https://doi.org/10.1007/BF02550087

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  • DOI: https://doi.org/10.1007/BF02550087

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