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Prognostic value of an assessment of ABH(0) isoantigens and thomsen-friedenreich (TF) antigen expression in patients with urinary bladder tumours

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Abstract

The discriminating and prognostic value of the expression of ABH(0) and TF antigens in tumour cells of 76 patients with urinary bladder tumours was evaluated. In patients with superficial tumours the most frequently defined phenotype was ABH(−) TF(+) and in those with deep tumours ABH(−) TF(−). The lowest frequency of recurrences was seen in patients with TECr(+) antigenic phenotype and no patient died in this group. The mean lifesoan of patients with TF(−) tumours was shorter (21) months than of those with TF(+_ tumours. For detection of tumours with higher risk of recurrences and analysis of the combination of markers revealed to be more predictive than analysis of a single marker.

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Authors and Affiliations

  1. Clinic and Department of Urology, The Nicolas Copernicus Academy of Medicine, Cracow, Poland

    Z. F. Dobrowolski

  2. Department of Tumour Immunology The Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

    D. Dus & C. Radzikowski

  3. Clinical Immunology, The Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

    J. Hałasa

Authors
  1. Z. F. Dobrowolski
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  2. D. Dus
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  3. J. Hałasa
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  4. C. Radzikowski
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Additional information

The clinical part of the research was carried out within the Medical Academy Research Projects and was financially supported from Grant No. DN-B-501-W1-50.

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Dobrowolski, Z.F., Dus, D., Hałasa, J. et al. Prognostic value of an assessment of ABH(0) isoantigens and thomsen-friedenreich (TF) antigen expression in patients with urinary bladder tumours. International Urology and Nephrology 27, 395–404 (1995). https://doi.org/10.1007/BF02550074

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  • DOI: https://doi.org/10.1007/BF02550074

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