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Effect of papaverine on solute transport in peritoneal dialysis

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Abstract

Since vasodilators enhance the peritoneal solute transport, the influence of intraperitoneal papaverine was studied. To verify the action of papaverine on peritoneal transport we selected 33 patients on acute peritoneal dialysis and performed two 2-hour cycles with 2000 cc of a 1.5% solution, adding 40 mg of papaverine to the fourth cycle. At the end of the third and fourth cycles blood and dialysate were drawn for urea, creatinine, glucose and protein levels, using peritoneal clearances of urea and creatinine, glucose absorption and net protein loss to compare the two cycles. We found no significant change in solute transport (urea clearance p>0.0.5; creatinine clearance, protein loss and glucose absorption p>0.1).

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  1. Department of Nephrology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey

    N. Y. Ilker, S. Özgür & S. Cetin

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  1. N. Y. Ilker
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  2. S. Özgür
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  3. S. Cetin
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Ilker, N.Y., Özgür, S. & Cetin, S. Effect of papaverine on solute transport in peritoneal dialysis. International Urology and Nephrology 21, 119–123 (1989). https://doi.org/10.1007/BF02549910

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  • DOI: https://doi.org/10.1007/BF02549910

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