Abstract
Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine. Trazodone-related priapism uniformly required surgical procedures and resulted in impotence in two of three cases. In contrast, papaverine-associated priapism was successfully managed by aspiration and all seven patients continued to respond to intracorporal treatment. Iatrogenic priapism is an important complication of therapy with vasoactive drugs.
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Winter, C. C., McDowell, G.: Experience with 105 patients with priapism: Update review of all aspects.J. Urol., 140, 980 (1988).
Hauri, D., Spycher, M., Brahlman, W.: Erection and priapism: a new pathophysiologic concept.Urol. Int., 38, 138 (1983).
Spycher, M. A., Hauri, D.: Ultrastructure of the erectile tissue in priapism.J. Urol., 135, 142 (1983).
Pohl, J., Pott, B., Kleinhaus, G.: Priapism: a three-phase concept of management according to aetiology and prognosis.Br. J. Urol., 58, 113 (1986).
Arber, J. C., Lui, T. F., Luo, J., Juenemann, I., Tanagho, E. A.: Priapism induced by chlorpromazine and trazodine: mechanisms of action.J. Urol., 137, 1039 (1987).
Brindley, G. S.: Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence.Br. J. Psych., 143, 332 (1983).
Scher, M., Krieger, J. N., Jergens, S.: Trazodone and priapism.Am. J. Psychol., 140, 1362 (1983).
Sacks, M., Miller, F., Gunn, J., Paul, E. S. A.: Unusual erectile activity as a side effect of trazodone.Hosp. Comm. Psych., 36, 298 (1985).
Zorgniotti, A. I., Lefleur, R. S.: Auto-injection of the corpus cavernosum with a vasoactive drug combination for vasculogenic impotence.J. Urol., 133, 39 (1985).
Sidi, A. A., Cameron, J. S., Duffy, L. M., Lange, P. H.: Intracavernous drug-induced erections in the management of male erectile dysfunction: experience with 100 patients.J. Urol., 135, 704 (1986).
Lui, T. E., Helstrom, W. J. G., McAnich, J. W., Tanagho, E. A.: Priapism: a refined approach to diagnosis and treatment.J. Urol., 136, 104 (1986).
Venable, D. D., Hastings, D., Misra, R. P.: Unusual metastatic patterns of prostatic adenocarcinoma.J. Urol., 130, 980 (1983).
Nelson, J. H., III, Winter, C.: Priapism: evolution of management in 48 patients in a 22 year series.J. Urol., 117, 455 (1977).
Bertram, R. A., Webster, G. D., Carson, C. C.: Priapism: etiology, treatment and results in a series of 35 presentations.Urology, 26, 229 (1985).
Pantaleo-Gandais, M., Chacon, O., Chalbaud, R., Plaza, N.: Priapism: evaluation and treatment.Urology, 24, 345 (1984).
Maurice-Williams, R. S., Maugh, H. T.: Priapism is a feature of claudication of the cauda equina.Surg. Neurol., 23, 626 (1985).
Kavanaugh, G. J., Svein, H. J., Holman, C. B.: Pseudoclaudiscation syndrome produced by compression of cauda equina.J. Am. Med. Assoc. 206, 2477 (1968).
Forsberg, L., Mattiason, A., Olsson, A. M.: Priapism—conservative treatment versus surgical procedures.Br. J. Urol., 53, 374 (1981).
Klein, E. A., Montague, D. K., Sterger, E.: Priapism associated with the use of IV fat emulsion: case reports and postulated pathogenesis.J. Urol., 133, 857 (1985).
Ekstrom, B., Olsson, A. M.: Priapism in patients treated with total parenteral nutrition.Br. J. Urol., 59, 170 (1987).
Branger, B., Ramperez, P., Oules, R., Balducchi, J. P., Fourcade, J., Shaldon, S., Costa, P., Louis, J. F., Navratil, H.: Metaraminol for haemodialysis-associated priapism.Lancet, 1, 641 (1985).
Gomez, E. A.: Neuroleptic-induced priapism.Texas Med., 81, 47 (1985).
Hanno, P. M., Lopez, R., Wein, A. J.: Trazodone-induced priapism.Br. J. Urol., 61, 94 (1988).
Adams, J. W., Soucheray, J. A.: Prazocin-induced priapism in a diabetic.J. Urol., 132, 1208 (1984).
Robbins, D. N., Crawford, E. D., Lackner, L. H.: Priapism secondary to prazocin overdose.J. Urol., 130, 975 (1983).
Halstead, D. S., Weigel, J. W., Noble, M. J., Mebust, W. K.: Papaverine-induced priapism: 2 case reports.J. Urol., 136, 109 (1986).
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Bardin, E.D., Krieger, J.N. Pharmacological priapism: Comparison of trazodone- and papaverine-associated cases. International Urology and Nephrology 22, 147–152 (1990). https://doi.org/10.1007/BF02549833
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DOI: https://doi.org/10.1007/BF02549833