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Pharmacological priapism: Comparison of trazodone- and papaverine-associated cases

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Abstract

Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine. Trazodone-related priapism uniformly required surgical procedures and resulted in impotence in two of three cases. In contrast, papaverine-associated priapism was successfully managed by aspiration and all seven patients continued to respond to intracorporal treatment. Iatrogenic priapism is an important complication of therapy with vasoactive drugs.

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Bardin, E.D., Krieger, J.N. Pharmacological priapism: Comparison of trazodone- and papaverine-associated cases. International Urology and Nephrology 22, 147–152 (1990). https://doi.org/10.1007/BF02549833

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