International Urology and Nephrology

, Volume 22, Issue 6, pp 561–566 | Cite as

The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients

  • A. Dmoszyńska-Giannopoulou
  • L. Janicka
  • B. Sokołowska
  • A. Ksi⇂żek
  • G. Orłowska
  • K. Janicki
Article

Abstract

In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.

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Copyright information

© Akadémiai Kiadó 1990

Authors and Affiliations

  • A. Dmoszyńska-Giannopoulou
    • 1
  • L. Janicka
    • 1
  • B. Sokołowska
    • 1
  • A. Ksi⇂żek
    • 1
  • G. Orłowska
    • 1
  • K. Janicki
    • 1
  1. 1.Department of Haematology and NephrologyMedical SchoolLublinPoland

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