Abstract
Serum and urine levels of tumour necrosis factor (TNF) which is a lymphokine was measured in patients with genitourinary cancer (either prostatic, bladder or testicular carcinoma) in order to find out whether there were elevated levels of TNF in those patients and if it was related to disease status.
Although the preliminary results are not conclusive, further research on TNF may prove this immunoprotein to be a potential diagnostic and therapeutic agent.
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Aggarwal, B. B., Aiyer, R. A., Pennica, D., Gray, P. W., Goeddel, D. V.: Human tumor necrosis factors: Structure and receptor interactions. In: Tumor Necrosis Factor and Related Cytotoxins. Ciba Foundation Symposium 131. Wiley and Sons Ltd., Chichester 1987.
Beutler, B., Cerami, A.: Cachectin: More than a tumor necrosis factor.N. Engl. J. Med., 316, 379 (1987).
Carswell, E., Old, L. J., Kassel, R. L., Green, S., Fiore, N., Williamson, B.: An endotoxin induced serum factor that causes necrosis of tumors.Proc. Natl. Acad. Sci., 72, 3666 (1975).
Beutler, B., Mahoney, J., LeTrang, N., Pekala, P., Cerami, A.: Purification of cachectin, a lipoprotein lipase suppressing hormone secreted by endotoxin induced RAW 264.7 cells.J. Exp. Med., 161, 984 (1985).
Palladino, M. A., Patton, J. S., Figari, I. S., Shalaby, M. R.: Possible relationships between in vivo antitumor activity and toxicity of tumor necrosis factor-alpha. In: Tumor Necrosis Factor and Related Cytotoxins. Ciba Foundation Symposium 131. Wiley and Sons Ltd., Chichester 1987.
Hass, P. E., Hotchkiss, A., Mohler, M., Aggarwal, B. B.: Characterization of specific high affinity receptors for human tumor necrosis factor on mouse fibroblasts.J. Biol. Chem., 260, 12214 (1985).
Aggarwal, B. B., Eessalu, T. E., Hass, P. E.: Characterization of receptors for human tumor necrosis factor and their regulation by gamma-interferon.Nature, 318, 665 (1985).
Shalaby, M. R., Palladino, M. R., Hirabayashi, S. E.: Receptor binding and activation of polymorphonuclear neutrophils by tumor necrosis factor alpha.J. Leukocyte Biol., 41, 196 (1987).
Petersen, C. M., Moller, B. K.: Immunological reactivity of tumor necrosis factor.Lancet, 1, 935 (1988).
Sherman, M. L., Spriggs, D. R., Arthur, K. A., Imamura, K., Frei, E., Kufe, D. W.: Recombinant human tumor necrosis factor administered as a five day continuous infusion in cancer patient: Phase I toxicity and effects on lipid metabolism.J. Clin. Oncol., 6, 344 (1988).
Ruff, M. R., Gifford, G. E.: Tumor necrosis factor. In: Pick, E. (ed.): Lymphokines. Academic Press, New York 1981; Vol. 2, 1988, p. 235.
Gifford, G. E., Flick, D. A.: Natural production and release of tumor necrosis factor. In: Tumor Necrosis Factor and Related Cytotoxins. Ciba Foundation Symposium 131. Wiley and Sons Ltd., Chichester 1987.
Ziegler, E. J.: Tumor necrosis factor in humans.N. Engl. J. Med., 318, 1533 (1988).
Tracey, K. J., Lowry, S. F., Cerami, A.: Physiological response to cachectin. In: Tumor Necrosis Factor and Related Cytotoxins. Ciba Foundation Symposium 131. Wiley and Sons Ltd., Chichester 1987.
Nawroth, P. P., Bank, I., handley, D., Cassimeris, J., Ckess, L., Stern, D.: Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1.J. Exp. Med., 163, 1363 (1986).
Michie, H. R., Manogue, K. R., Spriggs, D. R.: Detection of circulating tumor necrosis factor after endotoxin administration.N. Engl. J. Med., 318, 1481 (1988).
Scuderi, P., Lam, K. S., Ryan, K. J.: Raised serum levels of tumor necrosis factor in parasitic infections.Lancet, 2, 1364 (1986).
Flick, D. A., Gifford, G. E.: Pharmacokinetic of murine tumor necrosis factor.J. Immunopharmacol., 8, 89 (1986).
Haranaka, K., Satomi, N., Sakurai, A., Haranaka, R.: Antitumor effects of tumor necrosis factor: Cytotoxic or necrotizing activity and its mechanism. In: Tumor Necrosis Factor and Related Cytotoxins. Ciba Foundation Symposium 131. Wiley and Sons Ltd., Chichester 1987.
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Akdaş, A., Türkeri, L. & Akoĝlu, T. Serum and urine levels of tumour necrosis factor in patients with genitourinary cancer and their relevance to disease status. International Urology and Nephrology 22, 501–506 (1990). https://doi.org/10.1007/BF02549736
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DOI: https://doi.org/10.1007/BF02549736