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Long-term prognosis of chronic glomerulonephritis

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Abstract

The dependence of actuarial survival rates on morphological and clinical manifestation of chronic glomerulonephritis (CGN) has been studied in 520 patients followed up for 2–42 years. In grouping the patients along two sings—histological lesion and relapse incidence—the survival in different morphological forms of CGN was found to be similarly dependent on the illness activity. It was high in rare and the lowest in frequent and persisting relapses. Hypertension, high-grade tubulo-interstitial changes and sclerosis over 50 per cent of glomeruli indicate a poor prognosis as signs of severe renal damage under which each relapse may hasten the lethal outcome. Identification of the histological appearance is of high importance in CGN prognosis because of their different manifestations and tendency to relapse.

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References

  1. Beaufils, H., Alphonse, J. C., Guedon, J., Legrain, M.: Focal glomerulosclerosis: natural history and treatment. A report of 70 cases.Nephron, 21, 75 (1978).

    PubMed  CAS  Google Scholar 

  2. Bohle, A.: Die Bedeutung des Niereninterstitiums für die Nierenfunktion.Klin. Wochenschr., 60, 1186 (1982).

    Article  PubMed  CAS  Google Scholar 

  3. Cameron, J. S.: The natural history of glomerulonephritis. In: D. Black, N. Jones (eds): Renal Disease. Blackwell Scientific Publications, Oxford 1979, pp. 329–382.

    Google Scholar 

  4. Cutler, S. J., Ederer, F.: Maximum utilization of the life table method in analyzing survival.J. Chron. Dis., 6, 699 (1958).

    Article  Google Scholar 

  5. Czihal, E., Pap, I., Lachlein, L.: Zur Prognose der Glomerulonephritis—eine retrospective Verlaufsbeobachtung an 308 Patienten.Z. Klin. Med., 40, 191 (1985).

    Google Scholar 

  6. Davidson, A. M., Cameron, J. S., Kerr, D. N., Ogg, C. S., Wilkinson, R. W.: The natural history of renal function in untreated idiopathic membranous glomerulonephritis in adults.Clin. Nephrol., 22, 617 (1984).

    Google Scholar 

  7. Donadio, J. V., Torres, V. E., Velosa, J. A., Wagonier, R. D., Holley, K. E., Okamura, M., Ilstrup, D. M., Chi-Pin-Chu: Idiopathic membranous nephropathy: the natural history of untreated patients.Kidney Int., 33, 708 (1988).

    PubMed  Google Scholar 

  8. Fischbach, H., Bohle, A., Meyer, D., Edel, H. H., Frotscher, U., Kluthe, R., Renner, D., Rinsche, K., Scheler, F.: The morphological and clinical course of the different forms of glomerulonephritis.Klin. Wochenschr., 54, 105 (1976).

    Article  Google Scholar 

  9. Glassock, R. J., Cohen, A. H., Benett, C. M., Martinez-MacDonald, M.: Primary glomerular diseases. In: B. M. Brenner (ed.): The Kidney. Saunders, Philadelphia 1986, pp. 929–1013.

    Google Scholar 

  10. Habib, R., Levy, M.: Clinicopathological correlations in membranoproliferative GN (MPGN). Abstract 6th Int. Congress Nephrology, Firenze 1975, pp. 87–88.

  11. Kida, H., Asamoto, T., Yokoyama, N., Tomosugi, N., Hatteri, N.: Long-term prognosis of membranous nephropathy.Clin. Nephrol., 25, 64 (1986).

    PubMed  CAS  Google Scholar 

  12. Legrain, M., Beaufils, H., Guedon, J.: Die Prognose der chronischen Glomerulonephritis (Bericht über 298 Fälle).Z. Urol. Nephrol., 71, 445 (1978).

    PubMed  CAS  Google Scholar 

  13. Mallick, N. P., Short, C. D., Hunt, L. P.: How far since Ellis? (The Manchester study of glomerular disease).Nephron, 46, 113 (1987).

    Article  PubMed  CAS  Google Scholar 

  14. Müller, V.: Gegenwärtige Vorstellungen zur Therapie der Glomerulonephritis.Z. Urol. Nephrol., 74, 315 (1981).

    PubMed  Google Scholar 

  15. Natusch, R., Göbel, U., Mohnike, A., Scholz, D.: Zur Therapie der Glomerulonephritis.Dtsch. Ges. Wes., 34, 115 (1979).

    Google Scholar 

  16. Peto, R., Pike, M. C., Armitage, P., Breslaw, N. E., Cox, D. R., Howard, V., Mantel, N., McPherson, K., Peto, J., Smith, P. G.: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples.Br. J. Cancer, 9, 1 (1977).

    Google Scholar 

  17. Ratner, M., Serov, V. V., Warschavski, W. A., Rosenfeld, B., Subkin, M. L., Novikov, I. D., Sinn, N., Klinkmann, H.: Vorschlag zur klinischen Klassifizierung der chronischen Glomerulonephritis.Z. Urol. Nephrol., 80, 271 (1987).

    PubMed  CAS  Google Scholar 

  18. Ryabov, S. I., Stavskaya, V. V.: Different morphological patterns of glomerulonephritis.Therap. Arch., 66, 7 (1984).

    Google Scholar 

  19. Sarre, H., Kluthe, R., Oechslen, D., Yesdinsky, H. Y.: Einfluss von Kortikosteroiden auf die Überlebenszeit beim nephrotischen Syndrom des Erwachsenenalters. In: R. Kluthe (ed.): Medikamentöse Therapie bei Nierenerkrankungen. Georg Thieme Verlag, Stuttgart 1971, pp. 295–317.

    Google Scholar 

  20. Sarre, H.: Chronische Glomerulonephritis. In: H. Sarre(ed.): Nierenkrankheiten. Georg Thieme Verlag, Stuttgart 1976, pp. 295–317.

    Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, 1st Medical Institute, Leningrad, USSR

    S. I. Ryabov & V. V. Stavskaya

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  1. S. I. Ryabov
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  2. V. V. Stavskaya
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Ryabov, S.I., Stavskaya, V.V. Long-term prognosis of chronic glomerulonephritis. International Urology and Nephrology 23, 77–88 (1991). https://doi.org/10.1007/BF02549732

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