Skip to main content
SpringerLink
Log in

Immunohistochemical detection of beta-human chorionic gonadotropin in urothelial carcinoma

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

Histologic sections from the specimens of 60 patients with urothelial carcinoma were stained immunohistochemically to search for beta-human chorionic gonadotropin (B-HCG) production. There were 6 doubtful, 5 weak and 1 strong positive B-HCG stainings among 65 sections from 60 patients. De novo acquisition of B-HCG production capability of tumour cells seemed to be predictive for early haematogenous dissemination of the disease, but the data obtained in this particular study were insufficient to suggest B-HCG as a routine prognostic marker.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Soloway, M. S.: Evaluation and management of patients with superficial bladder cancer.Urol. Clin. North Am., 14, 771 (1987).

    PubMed  CAS  Google Scholar 

  2. Yamase, H. T., Wurzel, R. S., Nieh, P. T., Gondos, B.: Immunohistochemical demonstration of human chorionic gonadotropin in tumours of the urinary bladder.Ann. Clin. Lab. Sci., 15, 414 (1985).

    PubMed  CAS  Google Scholar 

  3. Shah, W. M., Newman, J., O'Brien, J. M., Considine, J.: Ectopic beta-human chorionic gonadotropin production by bladder urothelial neoplasia.Arch. Pathol. Lab. Med., 110 107 (1986).

    PubMed  CAS  Google Scholar 

  4. Dexeus, F., Logothetis, C., Hossan, E., Samuels, M. L.: Carcinoembryonic antigen and beta-human chorionic gonadotropin as serum markers for advanced urothelial malignancies.J. Urol., 136, 403 (1986).

    PubMed  CAS  Google Scholar 

  5. Johnson, D. E., Swanson, D. A., Eschenbach, A. C.: Tumours of the Genitourinary Tract. Appleton & Lange, USA (1988).

    Google Scholar 

  6. Javadpour, N.: Multiple cell markers in bladder cancer. Principles and clinical applications.Urol. Clin. North Am., 11, 609 (1984).

    PubMed  CAS  Google Scholar 

  7. Coon, J. S., Weinstein, R. S., Summers, J. L.: Blood group precursor T-antigen expression in human bladder carcinoma.Am. J. Clin. Pathol., 77, 692 (1982).

    PubMed  CAS  Google Scholar 

  8. Newman, A. J., Carlton, C. E., Johnson, S.: Cell surface A, B or O(H) blood group antigens as an indicator of malignant potential in stage A bladder carcinoma.J. Urol., 124, 27 (1980).

    PubMed  Google Scholar 

  9. Abel, P. D., Thorpe, S. J., Williams, G.: Blood group antigen expression in frozen sections of presenting bladder cancer: 3-year prospective follow-up of prognostic value.Br. J. Urol., 63, 171 (1989).

    Article  PubMed  CAS  Google Scholar 

  10. Richie, J. P., Blute, R. D., Waisman, J.: Immunologic indicators of prognosis in bladder cancer: the importance of cell surface antigens.J. Urol., 123, 22 (1980).

    PubMed  CAS  Google Scholar 

  11. Gustafson, H., Tribukait, B., Esposti, P. L.: DNA profile and tumour progression in patients with superficial bladder tumours.Urol. Res., 10, 13 (1982).

    Article  PubMed  CAS  Google Scholar 

  12. Summers, J. L., Coon, J. S., Ward, R. M.: Prognosis in carcinoma of the urinary bladder based upon tissue blood group ABH and Thomsen-Friedenreich antigen status and karyotype of the initial tumour.Cancer Res., 43, 934 (1983).

    PubMed  CAS  Google Scholar 

  13. Carter, H. B., Amberson, J. B., Bander, N. H.: Newer diagnostic techniques for bladder cancer.Urol. Clin. North Am., 14, 763 (1987).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey

    H. Özkardeş, A. Ergen, H. A. Özen, A. Ayhan & D. Remzi

Authors
  1. H. Özkardeş
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Ergen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. A. Özen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Ayhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Remzi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Özkardeş, H., Ergen, A., Özen, H.A. et al. Immunohistochemical detection of beta-human chorionic gonadotropin in urothelial carcinoma. International Urology and Nephrology 23, 5–11 (1991). https://doi.org/10.1007/BF02549722

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02549722

Keywords

Search

Navigation