Abstract
Total or partial renal ischaemia was studied in rats and pigs in a series of experiments, after (1) total devascularization (ligature of renal vessels and ureter); (2) ligature of isolated renal artery; (3) experimental embolization of renal artery by non-resorbable material; (4) devascularization of a specific renal segment by deep, strangulating sutures. Morphological studies showed that the resulting necrotization is represented most frequently by coagulation necrosis, less frequently by colliquating necrosis. Occlusion of the renal artery by embolization or ligature leads only to partial necrotization or atrophy. Total devascularization of the renal hilus or total devascularization of a specific renal segment by strangulating sutures leads to total destruction of the devascularized (devitalized) tissues. Within 8–12 weeks, the whole organ changes into a small residue of connective tissue. The possibility of the use of the devascularization technique in the treatment of tumours is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Almgard, L. E., Fernström, I., Haverlina, M., Lungquist, A.: Treatment of renal adenocarcinoma by embolic occlusion of the renal circulation.Br. J. Urol., 45, 474 (1973).
Barth, K., Bishoff, W., Wenzel, G.: Dauerhafte Ausschaltung der Nierendurchblutung durch Embolisation mit Mikrospheren.Urologie, 14, 250 (1975).
Bartley, O., Hultquist, G. T.: Spontaneous regression of hypernephromas.Acta Pathol. Microbiol. Scand., 27, 448 (1950).
Everson, T. C., Cole, W. H.: Spontaneous Regression of Cancer. W. B. Saunders Co., Philadelphia 1966.
Fortýn, K., Hradecký, J., Pazdera, J., Klaudy, J., Hruban, V., Dvořák, P., Matoušek, J., Tichý, J., Kolín, V.: Die Dünn- und Dickdarmdevaskularisation (Devitalisation) und einige Möglichkeiten der therapeutischen Ausnützung dieser Operationsmethode.Z. Exp. Chir., 18, 42 (1985).
Hlava, A., Steinhart, L., Navrátil, P.: Intraluminal obliteration of the renal arteries in kidney tumours.Radiology, 121, 323 (1976).
Keller, S. F., Rösch, S. F., Baur, G. M., Taylor, L. M., Dotter, C. T., Porter, J. M.: Percutaneous angiographic embolization: A procedure of increasing usefulness.Am. J. Surg., 142, 5 (1981).
Klemenc, J., Šimon, V., Křívánek, J., Votoček, F.: Surgical treatment of adenocarcinomas of the kidney after previous embolization of the renal artery (in Czech).Čas. Lék. Čes., 123, 1595 (1984).
Ljunggren, E., Holm, S., Karth, B., Pompeius, R.: Some aspects of renal tumours with special reference to spontaneous regression.J. Urol., 82, 553 (1959).
Löfgren, F.: Das topographische System der malphigischen Pyramiden der Menschenniere. Haban Ohssons Boktrickerei, Lund 1942.
Madden, J. L., Kandalaft, S.: Clinical evaluation of electrocoagulation in the treatment of cancer of the rectum.Am. J. Surg., 122, 347 (1971).
Paster, S. B., Berggreen, P., Schwarz, H.: Percutaneous catheter-aided infarction of renal tumors: a preliminary report.J. Urol., 114, 351 (1975).
Sophocles, A. M., Nadler, S. H.: Immunologic aspects of cancer.Surg. Gynecol. Obstet., 133, 321 (1971).
Stjernsward, J., Almgard, L. E., Franzen, S., Schreeb, T., Waldström, L. B.: Tumour-distinctive cellular immunity to renal carcinoma.Clin. Exp. Immunol., 6, 963 (1970).
Strauss, A. A., Appel, M., Saphir, O.: Immunologic resistance to carcinoma produced by electrocoagulation.Surg. Gynecol. Obstet., 121, 989 (1965).
Thomas, T. J., Hodgson, N. B., Maddison, E.: Therapeutic ureteral obstruction and renal artery embolization.J. Urol., 114, 518 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fortýn, K., Hradecký, J., Hruban, V. et al. Morphology of regressive changes in the kidney following experimental ischaemia. International Urology and Nephrology 19, 9–19 (1987). https://doi.org/10.1007/BF02549672
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02549672