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Central noradrenergic neurons and vascular non-collagen protein in the initial phase of two-kidney, one-clip renovascular hypertension

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Abstract

Rats had been given intraventricular injection of 6-hydroxydopamine (6-OHDA) before clipping the unilateral renal artery (2K-1C) that caused selective ablation of the central noradrenergic neurons. Central catecholamines and thein vivo incorporation of3H-proline into vascular non-collagen protein were determined in 2K-1C rats in the acute hypertensive stage.

It is suggested that increased non-collagen protein synthesis in the mesenteric artery and the low level of hypothalamic norepinephrine concentration may participate in the development of 2K-1C hypertension in rats.

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References

  1. Benarroch, E. E., Balda, M. S., Finkelman, S., Nahmod, V. E.: Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin.Neuropharmacol., 22, 29 (1983).

    Article  CAS  Google Scholar 

  2. Bloom, F. E., Algeri, S., Groppetti, A., Revuelta, A., Costa, E.: Lesions of central norepinephrine terminals with 6-hydroxydopamine on catecholamine-containing neurons in the rat brain.J. Neurochem., 17, 269 (1970).

    Article  Google Scholar 

  3. Bravo, E. L., Tarazi, R. C., Dustan, H. P., Fouad, F. M.: The sympathetic nervous system and hypertension in primary aldosteronism.Hypertension, 7, 90 (1985).

    PubMed  CAS  Google Scholar 

  4. Brody, M. J., Barron, K. W., Berecek, K. H., Faber, J. E., Lappe, R. W.: Neurogenic mechanism of experimental hypertension. In: J. Genest, O. Kuchel, P. Hamet, M. Cantin (eds): Hypertension, Physiology and Treatment, second edition. McGraw-Hill Book Co., New York-St. Louis-San Francisco-Auckland-Bogotá-Guatemala-Hamburg-Lisbon-London-Madrid-Mexico-Montreal-New Delhi-Panama-Paris-San Juan-São Paulo-Singapore-Sydney-Tokyo-Toronto 1983, p. 117.

    Google Scholar 

  5. Chalmers, J. P., Reid, J. L.: Participation of central noradrenergic neurons in arterial baroreceptor reflexes in the rabbit. A study with intracisternally administered 6-hydroxydopamine.Circ. Res., 26, 789 (1972).

    Google Scholar 

  6. Clark, D. W. J., Jones, D. R., Phelan, E. L., Devine, C. E.: Blood pressure and vascular resistance in genetically hypertensive rats treated at birth with 6-hydroxydopamine.Circ. Res., 293 (1978).

  7. Day, M. D., Roach, A. G.: β-adrenergic receptors in the central nervous system of the cat concerned with control of arterial blood pressure and heart rate.Nature, 242 (1973).

  8. Finch, L., Leach, G. D. H.: The contribution of the sympathetic nervous system to the development and maintenance of experimental hypertension in the rat.Br. J. Pharmacol., 39, 317 (1970).

    PubMed  CAS  Google Scholar 

  9. Folkow, B.: Physiological aspect of primary hypertension.Physiol. Rev., 62, 347 (1982).

    PubMed  CAS  Google Scholar 

  10. Garrigues, A.-M., Cazala, P.: Central catecholamine metabolism.Brain Res., 265, 265 (1983).

    Article  PubMed  CAS  Google Scholar 

  11. Haeusler, G., Finch, L., Thoenen, H.: Central adrenergic neurons and the initiation and development of experimental hypertension.Experientia, 28, 1200 (1972).

    Article  PubMed  CAS  Google Scholar 

  12. Hjemdahl, P., Daleskog, M., Kahn, T.: Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: comparison with a radioenzymatic method.Life Sci., 25, 131 (1979).

    Article  PubMed  CAS  Google Scholar 

  13. Katholi, R. E., Winternitz, S. R., Oparil, S.: Decrease in peripheral sympathetic nervous system activity following renal denervation or unclipping in the one-kidney one-clip Goldblatt hypertensive rat.J. Clin. Invest., 69, 55 (1982).

    Article  PubMed  CAS  Google Scholar 

  14. Katholi, R. E., McCann, W. P., Woods, W. T.: Intrarenal adenosine produces hypertension via nerves in the one-kidney, one-clip rat.Hypertension, 7 (Suppl. 1), 1 (1985).

    Google Scholar 

  15. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., Randall, R. J.: Protein measurement with the Folin phenol reagent.J. Biol. Chem., 193, 265 (1951).

    PubMed  CAS  Google Scholar 

  16. Maruyama, Y., Oshima, T., Nakajima, E.: Simultaneous determination of catecholamines in rat brain by reversed-phase liquid chromatography with electrochemical detection.Life Sci., 26, 1115 (1980).

    Article  PubMed  CAS  Google Scholar 

  17. Nagatsu, T., Ikuta, K., Numata, Y., Kato, T., Sano, M.: Vascular and brain dopamine β-hydroxylase activity in young genetically hypertensive rats.Science, 191, 290 (1975).

    Article  Google Scholar 

  18. Nakada, T., Loevenberg, W.: Lysine incorporation in vessels of spontaneously hypertensive rats: effects of adrenergic drugs.Eur. J. Pharmacol., 48, 87 (1978).

    Article  PubMed  CAS  Google Scholar 

  19. Nakada, T., Yamori, Y.: The role of vascular protein and renin in chronic two-kidney, one-clip Goldblatt hypertension.Clin. Exper. Hypertension, A4(3), 477 (1982).

    Google Scholar 

  20. Nakada, T., Koike, H., Katayama, T.: Participation of central norepinephrine in the development of two-kidney, one-clip Goldblatt hypertension.J. Urol., 135, 1066 (1986).

    PubMed  CAS  Google Scholar 

  21. Palkovits, M.: Isolated removal of hypothalamic or other brain nuclei of the rat.Brain Res., 59, 449 (1973).

    Article  PubMed  CAS  Google Scholar 

  22. Rascher, W., Schömig, A., Dietz, R., Weber, J., Gross, F.: Plasma catecholamine, noradrenaline metabolism and vascular response in desoxycorticosterone acetate hypertension of rats.Eur. J. Pharmacol., 75, 255 (1981).

    Article  PubMed  CAS  Google Scholar 

  23. Saavedra, J., Grobecker, H., Axelrod, J.: Changes in central catecholaminergic neurons in the spontaneously (genetic) hypertensive rat.Circ. Res., 42, 522 (1978).

    Google Scholar 

  24. Skosey, J. L., Zak, R., Martin, A. F., Aschenprenner, V., Rabinowitz, M.: Biochemical correlates of cardiac hypertrophy. V. Labeling of collagen, myosin and nuclear DNA during experimental myocardial hypertrophy in the rat.Circ. Res., 31, 145 (1972).

    PubMed  CAS  Google Scholar 

  25. Virtanen, R., MacDonald, E.: Comparison of the effects of detomidine and exylazine on some α2-adrenoceptor-mediated responses in the central and peripheral nervous systems.Eur. J. Pharmacol., 115, 277 (1985).

    Article  PubMed  CAS  Google Scholar 

  26. Wagner, J., Vitali, P., Palfreyman, M. G., Zraika, M., Huot, S.: Simultaneous determination of 3,4-dihydroxyphenylamine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in rat cerebrospinal fluid and by high-performance liquid chromatography with electrochemical detection.J. Neurochem., 38, 1241 (1982).

    Article  PubMed  CAS  Google Scholar 

  27. Yamabe, H., Lovenberg, W.: Increased incorporation of14C-lysine into vascular proteins of the spontaneously hypertensive rat.Eur. J. Pharmacol., 29, 109 (1974).

    Article  PubMed  CAS  Google Scholar 

  28. Yamori, Y., Nakada, T., Lovenberg, W.: Effect of antihypertensive therapy on lysine incorporation into vascular protein of the spontaneously hypertensive rat.Eur. J. Pharmacol., 38, 349 (1976).

    Article  PubMed  CAS  Google Scholar 

  29. Zimmerman, B. G., Mommsen, C., Kraft, E.: Sympathetic and renin-angiotensin system influence on blood pressure and renal blood flow of two-kidney, one-clip Goldblatt hypertensive dog.Hypertension, 2, 53 (1980).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan

    T. Nakada, H. Koike & T. Katayama

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  1. T. Nakada
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  2. H. Koike
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  3. T. Katayama
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Nakada, T., Koike, H. & Katayama, T. Central noradrenergic neurons and vascular non-collagen protein in the initial phase of two-kidney, one-clip renovascular hypertension. International Urology and Nephrology 20, 439–447 (1988). https://doi.org/10.1007/BF02549578

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  • DOI: https://doi.org/10.1007/BF02549578

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