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Acute experimental unilateral orchitis in the rabbit and its effect on fertility

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Abstract

We examined the nature of contralateral damage following unilateral orchitis to see if an immunologically mediated mechanism was present. Experimentally induced orchitis in 18 white New Zealand rabbits were examined and compared to 20 in the control groups. Serum antisperm antibody presence and bilateral testicular biopsies (Johansen biopsy score, mean seminiferous tubule diameter) were examined and pregnancy rates were noted. Acute orchitis seemed to be a causative factor in production of antisperm antibody and the presence of antisperm antibody caused histologic changes in contralateral testicles and therefore impaired fertility.

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Authors and Affiliations

  1. Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey

    M. Lekili, S. Tekgül, A. Ergen, Ç. Taşar & G. Hasçelik

  2. Department of Microbiology, Hacettepe University School of Medicine, Ankara, Turkey

    M. Lekili, S. Tekgül, A. Ergen, Ç. Taşar & G. Hasçelik

Authors
  1. M. Lekili
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  2. S. Tekgül
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  3. A. Ergen
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  4. Ç. Taşar
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  5. G. Hasçelik
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Lekili, M., Tekgül, S., Ergen, A. et al. Acute experimental unilateral orchitis in the rabbit and its effect on fertility. International Urology and Nephrology 24, 291–297 (1992). https://doi.org/10.1007/BF02549538

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  • DOI: https://doi.org/10.1007/BF02549538

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