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A double-blind placebo-controlled trial of omeprazole on urinary pH in healthy subjects

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Abstract

Urinary pH is related to urinary calculus formation as well as urinary infection. Omeprazole is an effective inhibitor of gastric acid secretion through inhibition of the parietal cell H+K+ATPase. In this study we have evaluated a possible effect of omeprazole on urine acidification. Ten healthy male subjects took placebo and omeprazole, 40 mg o.m., for 10 days in a double-blind placebo-controlled trial. Morning fasting urinary pH was measured on day 10 of each treatment course using a pH meter. No effect of omeprazole on urinary pH could be demonstrated. It is thus unlikely that it is necessary to take omeprazole treatment into consideration in stone screening. As omeprazole did not affect urinary pH, no urological side effects related to changes in urinary pH can be expected.

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References

  1. Holthöfer, H., Schultze, B. A., Parternack, G., Siegel, G. J., Spicer, S. S.: Immunocytochemical characterization of carbonic anhydrase-rich cells in the rat kidney collecting duct.Lab. Invest., 57, 150 (1987).

    PubMed  Google Scholar 

  2. Howden, C. W., Reid, J. L. Omeprazole, a gastric “proton pump inhibitor”: Lack of effect on renal handling of electrolytes and urinary acidification.Eur. J. Clin. Pharmacol., 26, 639 (1984).

    Article  PubMed  CAS  Google Scholar 

  3. Lind, T., Cederberg, C., Ekenved, G., Haglund, U., Olbe, L.: Effect of omeprazole—gastric proton pump inhibitor—on pentagastrin stimulated acid secretion in man.Gut, 240, 270 (1983).

    Google Scholar 

  4. Osther, P. J., Hansen, A. B., Røhl, H. F.: Renal acidification defects in medullary sponge kidney.Br. J. Urol., 61, 392 (1988).

    PubMed  CAS  Google Scholar 

  5. Osther, P. J., Hansen, A. B., Røhl, H. F.: Screening renal stone formers for distal renal tubular acidosis.Br. J. Urol., 63, 581 (1989).

    Article  PubMed  CAS  Google Scholar 

  6. Williams, G., Chisholm, G. D.: Stone screening and follow up are necessary?Br. J. Urol., 47, 745 (1976).

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery K, Odense University Hospital, Odense, Denmark

    P. J. Osther, L. Rasmussen & S. A. Pedersen

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  1. P. J. Osther
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  2. L. Rasmussen
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  3. S. A. Pedersen
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Osther, P.J., Rasmussen, L. & Pedersen, S.A. A double-blind placebo-controlled trial of omeprazole on urinary pH in healthy subjects. International Urology and Nephrology 24, 229–231 (1992). https://doi.org/10.1007/BF02549529

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  • DOI: https://doi.org/10.1007/BF02549529

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