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Determination of codeine phosphate and codeine in thermal characterization by differential scanning calorimetry

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Abstract

Thermal behaviour of codeine phosphate and codeine crystallized at the several solvents system was studied by DSC, and then, the kinetic parameters and thermochemical data have been obtained. We have found that codeine phosphate and codeine exist in a number of polymorphic formes which may inflicence the bio-availability.

Zusammenfassung

Mittels DSC wurde die thermische Charakterisierung von aus verschiedenen Lösungsmitteln kristallisiertem Kodeinphosphat und Kodein getätigt und anschließend die kinetischen Parameter und thermochemischen Angaben ermittelt. Es wurde festgestellt, daß Kodeinphosphat und Kodein in einer Reihe von polymorphen Formen existieren, welche die Bioverfügbarkeit beeinflussen können.

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Authors and Affiliations

  1. Division of Pharmaceutical Chemistry, National Institute for the Control of Pharmaceutical and Biological Products, Ministry of Health, 100050, Beijing, P. R. China

    Lahu Yang, Hua Yin, Wehua Zhu & Suhua Niu

Authors
  1. Lahu Yang
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  2. Hua Yin
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  3. Wehua Zhu
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  4. Suhua Niu
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Yang, L., Yin, H., Zhu, W. et al. Determination of codeine phosphate and codeine in thermal characterization by differential scanning calorimetry. Journal of Thermal Analysis 45, 207–210 (1995). https://doi.org/10.1007/BF02548681

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  • DOI: https://doi.org/10.1007/BF02548681

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