Skip to main content
SpringerLink
Log in

Pseudopolymorphism and phase stability of 7-piperidino-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-2-one (DN-9693)

  • Published:
Journal of thermal analysis Aims and scope Submit manuscript

Abstract

The phase stabilities of three pseudopolymorphs of DN-9693 were studied by using thermogravimetry and differential thermal analysis. The thermal dehydration of DN-9693·2HCl·H2O proceeds by the mechanism of two-dimensional growth of nuclei. The thermal dehydration of 0.5 mol of H2O per mol of DN-9693·2HCl·2H2O, and that of 2 mol of H2O per mol of DN-9693·2HCl·3H2O, proceed by the mechanisms of three-dimensional diffusion and three-dimensional phase boundary reaction, respectively, but the dehydration followed overlaps with the thermal elimination of HCl. The half-lives for the dehydration at 25°C show that DN-9693·2HCl·H2O is the most stable form.

Zusammenfassung

Mittels TG und DTA wurde die Phasenstabilität von drei Pseudopolymorphen von DN-9693 untersucht. Die thermische Dehydratation von DN-9693·2HCl·H2O erfolgt über einen zweidimensionalen Kernwachstumsmechanismus. Die thermische Dehydratation von 0.5 mol Wasser pro Mol DN-9693·2HCl·2H2O bzw. die von 2 mol Wasser pro Mol DN-9693·2HCl·3H2O erfolgt über den Mechanismus der dreidimensionalen Diffusion beziehungsweise einer dreidimensionalen Phasengrenzschichtreaktion, jedoch ist die Dehydratation durch die thermische Eliminierung von HCl überlagert. Die Halbwertszeit für die Dehydratation bei 25°C zeigt, daß DN-9693·2HCl·H2O die stabilste Form ist.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. F. Ishikawa, J. Saegusa, K. Inamura, K. Sakuma and S. Ashida, J. Med. Chem., 28 (1984) 1387.

    Article  Google Scholar 

  2. H. Kitaoka, K. Ohya and M. Sano, Yakugaku Zasshi, 102 (1982) 428.

    CAS  Google Scholar 

  3. T. Ozawa, Bull. Chem. Soc. Jpn., 38 (1965) 1881.

    Article  CAS  Google Scholar 

  4. T. Ozawa, Bull. Chem. Soc. Jpn., 57 (1984) 639.

    Article  CAS  Google Scholar 

  5. J. H. Sharp, G. W. Brindley and B. N. N. Achar, J. Am. Ceram. Soc., 49 (1966) 379.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, 134, Tokyo, Japan

    H. Kitaoka & K. Ohya

Authors
  1. H. Kitaoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Ohya
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kitaoka, H., Ohya, K. Pseudopolymorphism and phase stability of 7-piperidino-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-2-one (DN-9693). Journal of Thermal Analysis 44, 1047–1056 (1995). https://doi.org/10.1007/BF02547532

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02547532

Keywords

Search

Navigation