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Thermal stability of products prepared by the combination of cyclodextrins and zeolites

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Abstract

Derivatographic and calorimetric measurements were used to study the thermal properties of combined inclusion compounds of zeolite-cyclodextrin type and of zeolite-cyclodextrin-pharmaceutical type. There were differences in the characteristic decomposition temperature intervals and in the modes of cyclodextrin and pharmaceutical liberation from the products. Calorimetric measurements revealed that the process in the newly-formed complex host is connected with a glass transition.

The products are intended for use in veterinary medicine.

Zusammenfassung

Zur Untersuchung der thermischen Eigenschaften von kombinierten Einschlußverbindungen vom Zeolith-Cyclodextrin-Typ und vom Zeolith-Cyclodextrin-Arzneimittel-Typ wurden derivatografische und kalorimetrische Messungen verwendet. Es gabe Unterschiede bei den charakteristischen Zersetzungstemperaturintervallen sowie in der Art der Freisetzung von Cyclodextrin und Arzneimittel aus den Produkten. Kalorimetrische Messungen zeigten, daß der Prozeß im neugebildeten Kompelxwirt mit einer Glasumwandlung verknüpft ist.

Die Produkte sind für einen Einsatz in der Veterinärmedizin vorgesehen.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Šafarik’s University, Moyzesova 11, 041 54, Košice, Slovakia

    P. Mondík, Anna Sopková & P. Králik

Authors
  1. P. Mondík
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  2. Anna Sopková
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  3. P. Králik
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Mondík, P., Sopková, A. & Králik, P. Thermal stability of products prepared by the combination of cyclodextrins and zeolites. Journal of Thermal Analysis 44, 837–846 (1995). https://doi.org/10.1007/BF02547268

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  • DOI: https://doi.org/10.1007/BF02547268

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