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Changes in the composition of polysaccharides during the fusion of epiphyses in normal and lathyritic rats

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Abstract

Using histological and histochemical methods the changes within the distal epiphysis of the tibia and the calcanear epiphysis were investigated in normal and aminoacetonitrile-fed lathyritic rats during the period in which closure normally occurs. Only in the normal rats were these epiphyseal plates entirely replaced by bone in time. In the lathyritic animals, endochondral bone formation was reduced and the closure of the epiphyses failed to occur or was delayed. However, similar changes in the composition of polysaccharides were observed in the epiphyseal cartilage of both the normal and the lathyritic rats, which have been considered until now as specific only in experimental lathyrism.

Résumé

Les modifications de l’épiphyse distale du tibia et de celle du calcaneum on été étudiées histologiquement et histochimiquement au moment de la fermeture physiologique chez des rats normaux et des rats atteints de lathyrisme, en les alimentant avec de l’aminoacétonitrile. Seuls les rats normaux présentent une plaque épiphysaire remplacée par du tissu osseux dans un temps normal. Chez les animaux lathyriques, la formation osseuse enchondrale est diminuée et la fermeture des épiphyses est retardée ou ne se fait pas. Cependant, des changements similaires de composition en polysaccharides sont observés dans le cartilage épiphysaire des deux groupes.

Zusammenfassung

Die Veränderungen in den Epiphysenfugen des distalen Tibiaendes und des Calcaneus wurden mit histologischen und histochemischen Methoden an normalen und mit Aminoacetonitril gefütterten lathyritischen Ratten während des Zeitraumes untersucht, in dem diese Ephiphysenfugen normalerweise verknöchern.

Während bei den normalen Ratten die Verknöcherung dieser Epiphysenfugen rechtzeitig erfolgt, bleibt bei den lathyritischen Tieren der Verschluß aus oder ist verzögert.

Es konnten jedoch bei den normalen und bei den lathyritischen Tieren ähnliche Veränderungen in der Polysaccharidzusammensetzung des Epiphysenknorpels beobachtet werden, die bisher als spezifisch für den experimentellen Lathyrismus angesehen wurden.

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  1. Institute of Histology and Embryology, University of Vienna, Schwarzspanierstraße 17, A-1090, Vienna, Austria

    H. Plenk Jr.

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  1. H. Plenk Jr.
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Plenk, H. Changes in the composition of polysaccharides during the fusion of epiphyses in normal and lathyritic rats. Calc. Tis Res. 11, 70–77 (1973). https://doi.org/10.1007/BF02546596

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  • DOI: https://doi.org/10.1007/BF02546596

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