Abstract
The effect of diethylstilbestrol on healing experimental osseous defects in adult roosters was studied by means of I-125 photon absorptiometry. Although the two dose levels utilized in this study both resulted in elevated plasma calcium and lipid levels and significantly increased the mineral and organic fractions of femoral bone, diethylstillbestrol treatment over a six-week period had no effect on the rate or magnitude of mineralization in the repairing osseous defect.
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Beljan, J. R., Hellewell, A. B., Goldman, M.: The effect of calcium deficiency on healing of experimental fractures in the avian tarsus as determined by the Fracture Repair Ratio. Clin. Orthop.78, 277–285 (1971)
Braithwaite, G. D., Glascock, R. F., Riazuddin, Sh.: The effect of hexoestrol on calcium metabolism in the sheep. Brit. J. Nutr.28, 269–273 (1972).
Cameron, J. R., Grant, R., MacGregor, R.: An improved technique for the measurement of bone mineral content in vivo. Radiology78, 117 (1962).
Cameron, J. R., Sorensen, J.: Measurement of bone mineral in vivo: An improved method. Science142, 230–232 (1963)
Cox, A. C., Balloun, S. L.: Prediction of total skeleton mineralization from individual bone data. Poultry Sci.50, 186–194 (1971)
Cruess, R. L., Hong, K. C., Iida, K.: Effect of estrogen on the phospholipid metabolism of rat bone. Endocrinology92, 961–963 (1973)
Frings, C. S., Dunn, R. T.: A colorimetric method for determination of total serum lipids based on the sulfo-phospho-vanillin reaction. Amer. J. clin. Path.53, 89–91 (1970)
Hellewell, A. B., Beljan, J. R., Goldman, M.: Effect of chronic administration of a glucocorticoid (prednisolone) on the rate of healing of experimental osseous defects. Clin. Orthop.100, 349–355 (1974)
Henneman, D. H.: Effect of estradiol 17β on collagen biosynethesis, degradation and reutilizationin vivo. Biochem. biophys. Res. Commun.44, 326–332 (1971)
Henneman, D. H.: Treatment of postmenopausal osteoporosis with gonadal steroids. Semin. Drug Treat.2, 15–19 (1972).
Hertelendy, F., Taylor, T. G.: A comparison of the effects of oestradiol and hydrocortisone on the lipids, proteins, and on certain other components of the blood of mature cocks. Proc. 12th World’s Poultry Congr., p. 109–111. Sydney 1962
Hertelendy, F., Taylor, T. G.: The response of vitamin D-deficient cocks to oestrogen administration. Brit. Poultry Sci.6, 339–343 (1965)
Koskinen, E. V. S.: Effect of endocrine factors on callus development in experimental fractures. In: Callus formation symposium on the biology of fracture healing (St. Krompecher and E. Kerner, eds.), p. 315–322. Symp. Biol. Hung.7 (1967)
Kowalewski, K., Heron, F., Russell, J. C.: Effect of sex hormones on the metabolism of collagen and 45Ca by the bones of young gonadectomized rats. Acta endocr. (Kbh.)67, 740–755 (1971)
Mclean, F. C., Urist, M. R.: Bone: Fundamentals of the physiology of skeletal tissue, p. 119–124, Chicago: Univ. of Chicago Press 1968
Mulkey, G. J., Godfrey, E. F.: The effects of gonadal hormones on hyperossification in the domestic fowl. Poultry Sci.48, 1414–1420 (1969)
Raisz, L. B.: Physiological and pharmacologic regulation of bone resorption. New Engl. J. Med.282, 909–916 (1970)
Riggs, B. L., Jowsey, J., Goldsmith, R. S., Kelly, P. J., Hoffman, D. L., Arnaud, C. D.: Short- and long-term effects of estrogen and synthetic anabolic hormones in postmenopausal osteoporosis. J. clin. Invest.51, 1659–1663 (1972a)
Riggs, B. L., Jowsey, J., Kelly, P. J., Hoffman, D. L.: Treatment for postmenopausal and senile osteoporosis. Med. Clin. N. Amer.56, 989–997 (1972b)
Riggs, B. L., Jowsey, J., Goldsmith, R. S., Jones, J. D., Maher, F. T.: Effect of sex hormones on bone in primary osteoporosis. J. clin. Invest.48, 1065–1072 (1969)
Shai, F., Wallach, S.: Interaction of estradiol and calcitonin on the rat skeleton. Endocrinology93, 1044–1051 (1973)
Silberberg, M., Silberberg, R.: Steroid hormones and bone. In: The biochemistry and physiology of bone (G. H. Bourne, ed.), vol. 2, p. 401–442. New York and London: Academic Press 1971.
Sturkie, P. D.; Avian physiology, p. 578–582. Ithica: Comstock Publ. Assoc. 1965
Vaughn, J. M.: The physiology of bone, p. 217–223. Oxford: Oxford Univ. Press 1970
Whitson, S. W.: Estrogen-induced osteoid formation in the osteon of mature female rabbits. An electron microscopic study. Anat. Rec.173, 417–436 (1972)
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Hellewell, A.B., Beljan, J.R. & Goldman, M. The effect of diethylstilbestrol on the rate of osseous repair, bone integrity, and plasma calcium in the adult avian. Calc. Tis Res. 18, 233–239 (1975). https://doi.org/10.1007/BF02546242
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DOI: https://doi.org/10.1007/BF02546242