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Inhibition of growth of tubercle bacilli by ali-esterase inhibitors in various culture media

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Summary

The effect of the potent ali-esterase inhibitor E 600 (paraoxon) on the growth of tubercle bacilli is potentiated by the addition of Tween 80 to the medium. This may be due to a change in the permeability of the bacteria for the inhibitor.

Growth of tubercle bacilli from sputa is also inhibited by E 600 in the haemolysed human blood medium of Price. Cultures of tubercle bacilli in media with E 600 begin to grow after some time, when the inhibitor has broken down. The results obtained by the method of Price indicate that growth of the cultures does not originate from a few resistant cells but from the whole population which may have regained the ali-esterase activity essential to their growth.

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Authors and Affiliations

  1. Laboratory of Hygiene, University of Amsterdam, Amsterdam, Holland

    A. Charlotte Ruys

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  1. A. Charlotte Ruys
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Charlotte Ruys, A. Inhibition of growth of tubercle bacilli by ali-esterase inhibitors in various culture media. Antonie van Leeuwenhoek 20, 145–152 (1954). https://doi.org/10.1007/BF02543716

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  • DOI: https://doi.org/10.1007/BF02543716

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