Skip to main content
SpringerLink
Log in

On the mode of action of dialkyldithiocarbamates on moulds and bacteria

  • Published:
Antonie van Leeuwenhoek Aims and scope Submit manuscript

Summary

In the action of sodium dimethyldithiocarbamate on moulds and bacteria the formation of its 1∶1 and 1∶2 complexes with Cu++ from the medium plays a decisive role. These Cu complexes on the whole have a higher toxicity than NaDDC itself. The response pattern varies, however, according to the sensitivity of the organism used.

The activity of higher homologues of NaDDC is determined by the solubility of their 1∶2 complexes.

The mode of action of the dialkyldithiocarbamates is closely comparable with that of oxine and pyridine-2-thiol-N-oxide.

It is suggested that dithiocarbamates act by interference with some function of lipoic acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Albert, A., Gibson, M. I. andRubbo, S. D. 1953. Brit. J. Exp. Path.34, 119.

    PubMed  CAS  Google Scholar 

  2. Albert, A., Rees, C. W. andTomlinson, A. J. H. 1956. Brit. J. Exp. Path.37, 500.

    PubMed  CAS  Google Scholar 

  3. Albert, A. 1958. in “The Strategy of Chemotherapy”, ed.S. T. Cowan andE. Rowatt. Cambridge, p. 112.

  4. Albrecht, A. M. andBroquist, H. P. 1958. J. Bact.76, 651.

    PubMed  CAS  Google Scholar 

  5. Block, S. S. 1956. J. Agric. Food. Chem.4, 1042.

    Article  CAS  Google Scholar 

  6. Broquist, H. P. andStiffey, A. V. 1958. J. Bact.76, 646.

    PubMed  CAS  Google Scholar 

  7. Cruickshank, J. C. 1955. J. Hyg.54, 305.

    Article  Google Scholar 

  8. Dimond, A. E., Heuberger, J. W. andStoddard, E. M. 1941. Connecticut Agr. Exp. Sta. Bull.451, 635.

    Google Scholar 

  9. Goksøyr, J. 1955. Physiol. Plant.8, 719.

    Article  Google Scholar 

  10. Goksøyr, J. 1958. Universitetet i Bergen Åbok. nr. 3.

  11. Graham, W. D. 1951. J. Pharm. Pharmacol.3, 160.

    PubMed  CAS  Google Scholar 

  12. Gunsalus, I. C. 1953. J. cell. comp. Physiol. Suppl.1, 41.

    Google Scholar 

  13. Jakoby, W. B. 1958. J. Biol. Chem.232, 89.

    PubMed  CAS  Google Scholar 

  14. Janssen, M. J. 1957. Rec. trav. chim. Pays Bas.76, 827.

    CAS  Google Scholar 

  15. Janssen, M. J. 1958. J. inorg. nucl. Chem.8, 340.

    Article  CAS  Google Scholar 

  16. Kaars Sijpesteijn, A. andVan der Kerk, G. J. M. 1952. Antonie van Leeuwenhoek18, 83.

    Article  Google Scholar 

  17. Kaars Sijpesteijn, A. andVan der Kerk, G. J. M. 1954. Biochim. Biophys. Acta13, 545.

    Article  Google Scholar 

  18. Kaars Sijpesteijn, A. andVan der Kerk, G. J. M. 1954. Biochim. Biophys. Acta15, 69.

    Article  Google Scholar 

  19. Kaars Sijpesteijn, A., Janssen, M. J. andDekhuijzen, H. M. 1957. Nature180, 505.

    Article  Google Scholar 

  20. Kaars Sijpesteijn, A., Janssen, M. J. andVan der Kerk, G. J. M. 1957. Biochim. Biophys. Acta23, 550.

    Article  Google Scholar 

  21. Kaars Sijpesteijn, A. andJanssen, M. J. 1958. Nature182, 1313.

    Article  Google Scholar 

  22. Keilin, D. andHartree, E. F. 1949. Bioch. J.44, 215

    Google Scholar 

  23. Van der Kerk, G. J. M. andKlöpping, H. L. 1952. Rec. trav. chim. Pays Bas71, 1179.

    Google Scholar 

  24. Kjeldgaard, N. O. 1949. Acta pharmacol.5, 397.

    CAS  Google Scholar 

  25. Klöpping, H. L. andVan der Kerk, G. J. M. 1951. Rec. trav. chim. Pays Bas70, 917.

    Google Scholar 

  26. Nygaard, A. P. andSumner, J. B. 1952. Arch. Biochem. Biophys.39, 119.

    Article  PubMed  CAS  Google Scholar 

  27. Seaman, G. R. 1954. Fed. Proc.13, 731.

    PubMed  CAS  Google Scholar 

  28. Seaman, G. R. 1955. Fed. Proc.14, 136.

    Google Scholar 

  29. Sisler, H. D. andCox, C. E. 1955. Am. J. Bot.42, 351.

    Article  CAS  Google Scholar 

  30. Slater, E. C. 1949. Biochem. J.45, 130.

    PubMed  CAS  Google Scholar 

  31. Smale, B. C., Cox, C. E. andSisler, H. D. 1956. Phytopath.46, 27.

    Google Scholar 

  32. Smale, B. C. 1957. Doct. diss. series.25, 338. Microfilm Ann Arbor 25338.

    Google Scholar 

  33. Sorkin, E., Roth, W. andErlenmeyer, H. 1951. Experientia7, 64.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Organisch Chemisch Instituut T.N.O., Utrecht, Holland

    A. Kaars Sijpesteijn & M. J. Janssen

Authors
  1. A. Kaars Sijpesteijn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. J. Janssen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaars Sijpesteijn, A., Janssen, M.J. On the mode of action of dialkyldithiocarbamates on moulds and bacteria. Antonie van Leeuwenhoek 25, 422–438 (1959). https://doi.org/10.1007/BF02542865

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02542865

Keywords

Search

Navigation