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Secondary regulatory sites in rat liver cholesterol biosynthesis: Role of 5-pyrophosphomevalonate decarboxylase

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Lipids

Abstract

The activity of 5-pyrophosphomevalonate decarboxylase in 43,000 g supernatant fractions from livers and kidneys of male adult rats has been determined. Enzyme activity in liver is significantly increased when rats are fed a diet containing 3% cholestyramine (268% of control rats) and decreased when fed a diet containing 2% cholesterol (25% of control rats). No circadian rhythm of enzyme activity is found in liver or kidneys. These results show that variations in hepatic cholesterogenesis affect the activity of 5-pyrophosphomevalonate decarboxylase in a similar way as other enzymes involved in the biosynthesis of cholesterol.

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Authors and Affiliations

  1. Departamento de Medicina Experimental, Facultad de Medicina Oriente, Universidad de Chile, Casilla 10455, Santiago, Chile

    Ana María Jabalquinto & Emilio Cardemil

  2. Unidad de Bioquímica, Facultad de Medicina Occidente, Universidad de Chile, Casilla 10455, Santiago, Chile

    Ana María Jabalquinto & Emilio Cardemil

Authors
  1. Ana María Jabalquinto
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  2. Emilio Cardemil
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Jabalquinto, A.M., Cardemil, E. Secondary regulatory sites in rat liver cholesterol biosynthesis: Role of 5-pyrophosphomevalonate decarboxylase. Lipids 15, 196–199 (1980). https://doi.org/10.1007/BF02540970

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  • DOI: https://doi.org/10.1007/BF02540970

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