A lipid mobilizing factor in serum of tumor-bearing mice

Abstract

There is considerable evidence that the growing tumor requires a source of unsaturated fatty acids, but the nature of this source and the mechanism of mobilizing the fatty acids from it are obscure. These experiments make use of AKR mice with implanted adipose tisue labeled with 1-¹⁴C linoleic acid. With this experimental animal, it has been found that: (a) in the normal, fed mouse, fat is mobilized slowly and appears largely as respiratory CO₂, following oxidation, (b) in the normal, fasted mouse, fat is mobilized rapidly and appears largely as respiratory CO₂; (c) in the tumor-bearing, fed mouse, fat is mobilized rapidly and appears largely in the tumor; and (d) the serum from tumor-bearin mice, when injected into normal mice, produces an immediate massive fat mobilization that does not respond to feeding, whereas the serum from normal, fed mice does not. It is concluded that a mobilizing factor of unknown nature is present in the serum of tumor-bearing AKR mice.