Abstract
A chromatographic method is described for resolution of 9,10-vic-dihydroxyoctadecanoic acid. Thethreo anderythro isomers are both resolved into two enantiomers as di-3,5-dinitrophenylurethane derivatives by chiral-phase highperformance liquid chromatography on (S)-proline, (R)-1-(α-naphthyl) ethylamine stationary phase. Simultaneous separation of thethreo anderythro dihydroxy acid mixtures to the four enantiomers is possible by this method.
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Takagi, T. Resolution ofvic-dihydroxy acid diastereomers to four enantiomers by high-performance liquid chromatography. J Am Oil Chem Soc 71, 547–548 (1994). https://doi.org/10.1007/BF02540672
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DOI: https://doi.org/10.1007/BF02540672