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Effect of cholestyramine on bile acid metabolism in conventional rats

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Lipids

Abstract

Effects of cholestyramine on biliary secretion of cholesterol, phospholipids and bile acids and fecal excretion of sterols and bile acids were examined in Wistar male rats. Six rats were fed a basal diet, and the other six were fed a basal diet supplemented with 5% cholestyramine for eight days. Bile flow and biliary secretion of bile acids and phospholipids (per hour per rat) decreased with cholestyramine treatment, while biliary cholesterol secretion (per hour per rat) remained unchanged. In the biliary bile acid composition, a marked increase of chenodeoxycholic acid with a concomitant decrease of β-muricholic acid was observed in cholestyramine-treated rats. Fecal excretion of total sterols and bile acids increased about three-and four-fold, respectively, after cholestyramine treatment. The increase of fecal bile acids derived from cholic acid was more predominant than that derived from chenodeoxylcholic acid, resulting in an increase of the cholic acid group/chenodeoxycholic acid group ratio.

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Authors and Affiliations

  1. Shionogi Research Laboratories, Osaka, Japan

    Kiyohisa Uchida

  2. The Second Department of Internal Medicine, Osaka University Medical School, Fukushima-ku, 553, Osaka, Japan

    Yasuharu Imai, Sumio Kawata, Masami Inada, Shio Miyoshi, Yuzo Minami, Yuji Matsuzawa & Seiichiro Tarui

Authors
  1. Yasuharu Imai
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  2. Sumio Kawata
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  3. Masami Inada
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  4. Shio Miyoshi
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  5. Yuzo Minami
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  6. Yuji Matsuzawa
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  7. Kiyohisa Uchida
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  8. Seiichiro Tarui
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Imai, Y., Kawata, S., Inada, M. et al. Effect of cholestyramine on bile acid metabolism in conventional rats. Lipids 22, 513–516 (1987). https://doi.org/10.1007/BF02540367

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  • DOI: https://doi.org/10.1007/BF02540367

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