Skip to main content
SpringerLink
Log in

On the antifungal and antibacterial activity of some trisubstituted organogermanium, organotin and organolead compounds

  • Published:
Antonie van Leeuwenhoek Aims and scope Submit manuscript

Summary

The antifungal and antibacterial activities of a number of acetates of trialkyl- and triphenyl-substituted germanium, tin and lead have been investigated. All three groups contain active as well as inactive compounds. High activity was found for certain tin and lead compounds, whereas activity of the germanium compounds was much lower.

The activity optimum in the three trialkyl series varied according to the nature of the central atom and the type of organism used. A possible reason for these differences and a probable mode of action of the compounds are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aldridge, W. N. 1958. Biochem. J.69, 367.

    PubMed  CAS  Google Scholar 

  • Barnes, J. M. andStoner, H. B. 1958. Brit. J. Industr. Med.15, 15.

    PubMed  CAS  Google Scholar 

  • Barnes, J. M. andStoner, H. B. 1959. Pharmacol. Revs.11, 211.

    CAS  Google Scholar 

  • Blum, M. S. andPratt, J. J. 1960 J. Econ. Entomol.53, 445.

    CAS  Google Scholar 

  • Cremer, J. E. 1961. Ann. Occup. Hyg.3, 226.

    PubMed  CAS  Google Scholar 

  • Hof, T. andLuijten, J. G. A. 1959. Timber Technology67, 83.

    CAS  Google Scholar 

  • Ingham, R. K., Rosenberg, S. D. andGilman, H. 1960. Chem. Revs.60, 459.

    Article  CAS  Google Scholar 

  • Johnson, O. H. 1951. Chem. Revs.48, 259.

    Article  CAS  Google Scholar 

  • Kaars Sijpesteijn, A. 1959. Mededelingen Landbouwhogeschool Gent24, 850.

    Google Scholar 

  • van der Kerk, G. J. M. andLuijten, J. G. A. 1954. J. appl. Chem.4, 314.

    Article  Google Scholar 

  • van der Kerk, G. J. M. andLuijten, J. G. A. 1956. J. appl. Chem.6, 49.

    Article  Google Scholar 

  • van der Kerk, G. J. M. andLuijten, J. G. A. 1956. J. appl. Chem.6, 56.

    Article  Google Scholar 

  • Leeper, R. W., Summers, L. andGilman, H. 1954. Chem. Revs.54, 101.

    Article  CAS  Google Scholar 

  • Luijten, J. G. A. andvan der Kerk, G. J. M. 1955. “Investigations in the field of organotin chemistry”. Tin Research Institute, Greenford, Middlesex, England.

    Google Scholar 

  • Luijten, J. G. A. andvan der Kerk, G. J. M. 1961. J. appl. Chem.11, 35.

    Article  CAS  Google Scholar 

  • Manten, A., Klopping, H. L. andvan der Kerk, G. J. M. 1950. Antonie van Leeuwenhoek16, 282.

    Article  PubMed  CAS  Google Scholar 

  • Noltes, J. G., Luijten, J. G. A. andvan der Kerk, G. J. M. 1961. J. appl. Chem.11, 38.

    Article  CAS  Google Scholar 

  • Rijkens, F. 1960. “Organogermanium Compounds”. Institute for Organic Chemistry T.N.O., Holland. Publ. on behalf of the Germanium Research Committee.

  • Stoner, H. B., Barnes, J. M. andDuff, J. J. 1955. Brit. J. Pharmacol. Chemoth.10, 16.

    CAS  Google Scholar 

  • Willemsens, L. C. 1963. “Organolead Compounds”. Institute for Organic Chemistry T.N.O., Holland. Publ. on behalf of the Exp. Res. Progr. of the Lead Industries Assoc. To be published shortly.

Download references

Author information

Authors and Affiliations

  1. Organisch Chemisch Instituut T.N.O., Utrecht, The Netherlands

    A. Kaars Sijpesteijn, F. Rijkens, J. G. A. Luijten & L. C. Willemsens

Authors
  1. A. Kaars Sijpesteijn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Rijkens
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. G. A. Luijten
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. C. Willemsens
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sijpesteijn, A.K., Rijkens, F., Luijten, J.G.A. et al. On the antifungal and antibacterial activity of some trisubstituted organogermanium, organotin and organolead compounds. Antonie van Leeuwenhoek 28, 346–356 (1962). https://doi.org/10.1007/BF02538746

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02538746

Keywords

Search

Navigation