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The synergism between penicillin and kanamycin

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Summary

In vitro, a synergism was demonstrated between kanamycin and penicillin against penicillin-sensitive and penicillin-resistantStaphylococcus aureus, and against sixProteus strains. Strains ofE. coli, Klebsiella, Pseudomonas andEnterococcus showed a variable response to the combination of these two antibiotics.

On the basis of the results obtained, a number of conclusions were reached with regard to the range of indications for treatment with these combined antibiotics. Indications include infections caused by penicillin-resistantStaphylococcus and urinary infections caused byProteus bacteria. Infections by other bacteria may also constitute an indication, but it is maintained that in vitro determination of resistance is indispensable in all cases.

A number of arguments are presented against the use of a quantitatively fixed combination of the two antibiotics.

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Authors and Affiliations

  1. Bacteriological Laboratory, Department of Medicine, State University, Utrecht, The Netherlands

    R. P. Mouton & J. S. M. Van Rossem

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  1. R. P. Mouton
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  2. J. S. M. Van Rossem
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Mouton, R.P., Van Rossem, J.S.M. The synergism between penicillin and kanamycin. Antonie van Leeuwenhoek 27, 213–224 (1961). https://doi.org/10.1007/BF02538444

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