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The activity of some antibiotic combinations onSalmonella

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Summary

The effects of some antibiotics acting alone or in combination upon 72 strains of variousSalmonella species were investigated usingElek andHilson’s variant ofLederberg’s replica technique.

Chloramphenicol and tetracycline were found to act mainly bacteriostatically; streptomycin and neomycin varied in their action from bacteriostatic for some strains to bactericidal for other ones. The action of polymyxin B appeared to be more especially bactericidal.

But for a few exceptions no interaction was found between the combinations streptomycin-chloramphenicol and streptomycin-tetracycline. The pair neomycin-chloramphenicol was often antagonistic; neomycin-polymyxin B, on the other hand, prevailingly synergistic. Under the conditions of experimentation a pronounced synergism was noticed between polymyxin B and chloramphenicol.

The prospects of the latter synergistic combination as a possibly more radical means of combatingSalmonella infections are shortly discussed.

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References

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Authors and Affiliations

  1. National Institute of Public Health, Utrecht, the Netherlands

    A. Manten & J. A. de Nooy

Authors
  1. A. Manten
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  2. J. A. de Nooy
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Additional information

With the technical assistance of MissM. J. Wisse.

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Manten, A., de Nooy, J.A. The activity of some antibiotic combinations onSalmonella . Antonie van Leeuwenhoek 22, 231–236 (1956). https://doi.org/10.1007/BF02538332

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  • DOI: https://doi.org/10.1007/BF02538332

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