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1-O-alkyl-2,3-diacylglycerols in the skin surface lipids of the hairless mouse

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Lipids

Abstract

A neutral lipid class was isolated by thin-layer chromatography from the skin surface lipids of the hairless mouse. The fraction migrated faster than triglycerides and had a migration rate similar to that of diacyl alkanediols (diester wax). Upon deacylation, however, the long-chain diols were identified as 1-alkylglycerol ethers based on their chromatographic properties and on the mass spectra of their nicotinylidene derivatives. Thus, the skin lipid fraction was identified as 1-O-alkyl-diacylglycerol. The alkyl moieties were all saturated and even-numbered and ranged in chainlength from C16 to C22 with 1-O-hexadecylglycerol amounting to 34% of the total glycerol ether moieties. The fatty acids derived from this lipid fraction were mostly monoenoic with chainlengths ranging from C16 to C24. The major acyl component was eicosenoic acid (20∶1) representing 61% of the total fatty acids.

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Abbreviations

GC/MS:

gas chromatography/mass spectrometry

TLC:

thin-layer chromatography

HPTLC:

high-performance thin-layer chromatography

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Authors and Affiliations

  1. Laboratory of Applied Biochemistry, Faculty of Agriculture, University of The Ryukyus, Nishihara-Cho, 903-01, Okinawa-Ken, Japan

    Hirosuke Oku, Jyutaro Shudo, Junichi Nagata & Isao Chinen

  2. Cosmetic Laboratory, Kanebo Ltd., Kotobuki-Cho, Odawara-Shi, Kanagawa-Ken, Japan

    Kunio Mimura & Akinori Haratake

Authors
  1. Hirosuke Oku
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  2. Jyutaro Shudo
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  3. Kunio Mimura
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  4. Akinori Haratake
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  5. Junichi Nagata
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  6. Isao Chinen
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Oku, H., Shudo, J., Mimura, K. et al. 1-O-alkyl-2,3-diacylglycerols in the skin surface lipids of the hairless mouse. Lipids 30, 169–172 (1995). https://doi.org/10.1007/BF02538271

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  • DOI: https://doi.org/10.1007/BF02538271

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