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Studies of lipoproteins and fatty acids in maternal and cord blood of two racial groups in Trinidad

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Lipids

Abstract

The high mortality rate from coronary heart disease (CHD) among Indians compared to Negroes in Trinidad led us to test plasma lipid profiles to see whether dietary or genetic factors might be involved. There were no interracial differences in the composition of plasma cholesterol ester fatty acids of the tested women and neonates. This finding suggests that dietary fat does not account for the interracial difference in CHD, nor does the cause appear to be due to genetic differences in lipid profiles, as there was no significant difference between values for plasma triglycerides, total cholesterol, high density lipoprotein (HDL) cholesterol, apo-I, apo-II, apo B or cholesterol ester fatty acids in the cord blood of each racial group.

Blood samples were collected from 69 nonpregnant and 71 postpartum, fasted Negro and Indian women. Also taken were 71 umbilical cord blood samples. The mean triglyceride level was significantly lower in the Negro nonpregnant and postpartum women than in the Indians. HDL cholesterol and apo-I values were lower in the Indian women. There were no significant differences in the total cholesterol and apo B measurements. The triglyceride values for postpartum women were higher than those of the nonpregnant Negroes and Indians (75% and 47%, respectively), whereas the total cholesterol and HDL cholesterol, apo A-I and apo A-II ranged from 9% to 29% higher in the postpartum women. Apo B was about 40% higher postpartum in both ethnic groups.

The high CHD rate of Indians in Trinidad cannot be explained by dietary factors, plasma total cholesterol or fatty acid composition. However, the lower level of HDL cholesterol and plasma A-I could play a role in the higher CHD rate in Indians.

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Authors and Affiliations

  1. Department of Chemical Pathology, University of Ibadan, Ibadan, Nigeria

    G. Oladunni Taylor

  2. Departments of Medicine and Pathology, University of Washington School of Medicine and Northwest Lipid Research Clinic, Seattle, Washington

    John J. Albers

  3. Department of Medicine, University of Washington, 396 Ninth Ave., Rm. 465, 98104, Seattle, Washington

    G. Russell Warnick & Janet L. Adolphson

  4. Northwest Lipid Research Clinic, Harborview Medical Center, University of Washington, 396 Ninth Ave., Rm. 465, 98104, Seattle, Washington

    G. Russell Warnick & Janet L. Adolphson

  5. Departments of Chemical Pathology and Immunology, General Hospital, Port of Spain, Trinidad and Tobago, West Indies

    H. McFariane

  6. Department of Clinical Biochemistry, Royal Prince Alfred Hospital, 2050, Caperdown, NSW, Australia

    D. R. Sullivan

  7. Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands

    C. E. West

  8. County General Hospital, Sangre Grande, Trinidad and Tobago, West Indies

    V. Sri-Hari & R. Edwards

Authors
  1. G. Oladunni Taylor
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  2. John J. Albers
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  3. G. Russell Warnick
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  4. Janet L. Adolphson
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  5. H. McFariane
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  6. D. R. Sullivan
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  7. C. E. West
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  8. V. Sri-Hari
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Taylor, G.O., Albers, J.J., Warnick, G.R. et al. Studies of lipoproteins and fatty acids in maternal and cord blood of two racial groups in Trinidad. Lipids 22, 173–177 (1987). https://doi.org/10.1007/BF02537298

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  • DOI: https://doi.org/10.1007/BF02537298

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