Abstract
A saturated fat meal was given to 10 normal males both before and after pretreatment with UK38,485, a thromboxane synthetase inhibitor (Dazmegrel, Pfizer Central Research, Sandwich, Kent, United Kingdom). Following the fat meal at 2 and 4 hr there was laboratory evidence of platelet activation. Dazmegrel lowered baseline platelet activity and lessened platelet activation following the fat meal. This drug should be investigated further as a potential antithrombotic agent.
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Belch, J.J.F., Saniabadi, A.R., McLaughlin, K. et al. Platelet changes after a saturated fat meal and their prevention by dazmegrel, a thromboxane synthetase inhibitor. Lipids 22, 159–162 (1987). https://doi.org/10.1007/BF02537296
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DOI: https://doi.org/10.1007/BF02537296