Skip to main content
SpringerLink
Log in

The hypercholesterolemic effect of dietary coconut fatversus corn oil in hypo- or hyperresponsive rabbits is not exerted through influencing cholesterol absorption

  • Published:
Lipids

Abstract

In two inbred strains of rabbits with high or low response of plasma cholesterol to dietary saturatedversus polyunsaturated fatty acids, the efficiency of intestinal cholesterol absorption was measured. The feeding of a cholesterol-free purified diet containing saturated fatty acids in the form of coconut fat, when compared with a diet containing corn oil as polyunsaturated fatty acids, did not influence the efficiency of cholesterol absorption in the two rabbit strains. Irrespective of the dietary fat source, the hyperresponsive rabbits absorbed cholesterol more efficiently. It is concluded that the hypercholesterolemic effect of dietary coconut fatversus corn oil is not exerted by influencing cholesterol absorption.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

apo:

apolipoprotein

FNS:

fecal neutral steroids

OD:

oral dose

References

  1. Beynen, A.C., and Katan, M.B. (1985)Am. J. Clin. Nutr. 42, 560–563.

    PubMed  CAS  Google Scholar 

  2. Beynen, A.C., and West, C.E. (1981)Z. Tierphysiol. Tierernaehrg. u. Futtermittelkde 46, 233–239.

    CAS  Google Scholar 

  3. Kritchevsky, D., Tepper, S.A., Davidson, L.M., Fisher, E.A., and Klurfeld, D.M. (1989)Atherosclerosis 75, 123–127.

    Article  PubMed  CAS  Google Scholar 

  4. Huff, M.W., and Carroll, K.K. (1980)J. Lipid Res. 21, 546–558.

    PubMed  CAS  Google Scholar 

  5. Nagata, Y., Ishiwaki, N., and Sugano, M. (1982)J. Nutr. 112, 1614–1625.

    PubMed  CAS  Google Scholar 

  6. Vahouny, G.V., Chalcarz, W., Satchithanandam, S., Adamson, I., Klurfeld, D.M., and Kritchevsky, D. (1984)Am. J. Clin. Nutr. 40, 1156–1164.

    PubMed  Google Scholar 

  7. Beynen, A.C., West, C.E., Katan, M.B., and Van Zutphen, L.F.M. (1986)Nutr. Rep. Int. 33, 65–70.

    CAS  Google Scholar 

  8. Fox, R.R. (1975)Handbook on Genetically Standardized JAX Rabbits, The Jackson Laboratory, Bar Harbor.

    Google Scholar 

  9. Beynen, A.C., Meijer, G.W., Lemmens, A.G., Glatz, J.F.C., Versluis, A., Katan, M.B., and Van Zutphen, L.F.M. (1989)Atherosclerosis 77, 151–157.

    Article  PubMed  CAS  Google Scholar 

  10. Beynen, A.C., Van der Meer, R., West, C.E., Sugano, M., and Kritchevsky, D. (1986) inNutritional Effects on Cholesterol Metabolism (Beynen, A.C., ed.) pp. 29–45, Transmondial, Voorthuizen.

    Google Scholar 

  11. Kuyvenhoven, M.W., West, C.E., Van der Meer, R., and Beynen, A.C. (1986)J. Nutr. 116, 1395–1404.

    PubMed  CAS  Google Scholar 

  12. Abell, L.L., Levy, B.B., Brodie, B.B., and Kendall, F.E. (1952)J. Biol. Chem. 195, 357–366.

    CAS  Google Scholar 

  13. St. Clair, R.W., Wood, L.L., and Clarkson, T.B. (1981)Metabolism 30, 176–183.

    Article  PubMed  CAS  Google Scholar 

  14. Packard, C.J., and Shepherd, J. (1982)J. Lipid. Res. 23, 1081–1098.

    PubMed  CAS  Google Scholar 

  15. Reynier, M.O., Lafont, H., Crotte, C., and Gerolami, A. (1988)Ann. Nutr. Metab. 32, 15–22.

    Article  PubMed  CAS  Google Scholar 

  16. Kritchevsky, D., Tepper, S.A., Bises, G., and Klurfeld, D.M. (1983)Nutr. Res. 3, 229–236.

    Article  CAS  Google Scholar 

  17. Mott, G.E., Jackson, E.M., and Morris, M.D. (1980)J. Lipid Res. 21, 635–641.

    PubMed  CAS  Google Scholar 

  18. Spady, D.K., and Dietschy, J.M. (1985)Proc. Natl. Acad. Sci. USA 82, 4526–4530.

    Article  PubMed  CAS  Google Scholar 

  19. Ventura, M.A., Woollet, L.A., and Spady, D.K. (1989)J. Clin. Invest. 84, 528–537.

    Article  PubMed  CAS  Google Scholar 

  20. Brown, M.S., and Goldstein, J.L. (1986)Science 232, 34–47.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Laboratory Animal Science, State University, P.O. Box 80.166, 3508 TD, Utrecht, The Netherlands

    G. W. Meijer, A. G. Lemmens, A. Versluis, L. F. M. Van Zutphen & A. C. Beynen

Authors
  1. G. W. Meijer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. G. Lemmens
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Versluis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. F. M. Van Zutphen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. C. Beynen
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Meijer, G.W., Lemmens, A.G., Versluis, A. et al. The hypercholesterolemic effect of dietary coconut fatversus corn oil in hypo- or hyperresponsive rabbits is not exerted through influencing cholesterol absorption. Lipids 26, 340–344 (1991). https://doi.org/10.1007/BF02537195

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02537195

Keywords

Search

Navigation