, Volume 29, Issue 2, pp 145–147 | Cite as

The acute effects of a single very high dose of n−3 fatty acids on plasma lipids and lipoproteins in healthy subjects

  • N. Svaneborg
  • J. M. Møller
  • E. B. Schmidt
  • K. Varming
  • H. H. Lervang
  • J. Dyerberg


Forty healthy volunteers were allocated in a double blind, randomized study to receive either 20 g of n−3 polyunsaturated fatty acids (PUFA) or 20 g of n−6 PUFA at their evening meal. The effect on plasma lipids and lipoproteins of this single dose of fish oilvs. corn oil was studied the next morning, 14 h after ingestion. Plasma triglycerides and very low density lipoprotein-cholesterol significantly decreased (33%) after n−3 PUFA (P<0.001), and significantly (P<0.01) more than after intake of n−6 PUFA. The decrease in plasma triglycerides after n−3 PUFA ingestion was more pronounced in subjects with higher baseline levels of triglycerides (P<0.001). Total cholesterol decreased after both supplements, but did not differ between the supplements. Low density lipoprotein-cholesterol did not change, and high density lipoprotein-cholesterol significantly decreased in subjects given n−3 PUFA compared to baseline, but not when compared to subjects receiving n−6 PUFA. In conclusion, we have shown that a single very high dose of n−3 PUFA has a pronounced hypotriglyceridemic effect, which is directly related to the initial plasma level.


Plasma Lipid Plasma Triglyceride High Density Lipoprotein Cholesterol Level Evening Meal Cholesterol Ester Transfer Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



high density lipoproteins


low density lipoproteins


polyunsaturated fatty acids


very low density lipoproteins


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Copyright information

© American Oil Chemists’ Society 1994

Authors and Affiliations

  • N. Svaneborg
    • 1
    • 4
  • J. M. Møller
    • 2
  • E. B. Schmidt
    • 1
  • K. Varming
    • 3
  • H. H. Lervang
    • 4
  • J. Dyerberg
    • 5
  1. 1.Department of HaematologyAalborg HospitalAalborgDenmark
  2. 2.Department of GastroenterologyAalborg HospitalAalborgDenmark
  3. 3.Department of Clinical ImmunologyAalborg HospitalAalborgDenmark
  4. 4.Department of Clinical ChemistryAalborg HospitalAalborgDenmark
  5. 5.Medilab a.s.Copenhagen KDenmark

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