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The effect of dietary n−3 polyunsaturated fatty acids on HDL cholesterol in Chukot residentsvs muscovites

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Lipids

Abstract

Native Chukot Peninsula residents, in contrast to Muscovites, consume a diet rich in n−3 polyunsaturated fatty acids. This dietary peculiarity is reflected in differences in plasma lipid and apolipoprotein contents. The Chukot residents have lower contents of total cholesterol, triglyceride, LDL (low density lipoprotein) cholesterol and apolipoprotein B, but higher HDL (high density lipoprotein) cholesterol levels than do Muscovites. The apolipoprotein A-I levels were identical in both groups. A higher HDL cholesterol to apolipoprotein A-I ratio was determined in the coastline Chukot residents (0.52±0.01) than in Muscovites (0.43±0.01; p<0.01). In contrast to Muscovites, the coastline Chukot residents also had higher n−3 and lower n−6 polyunsaturated fatty acid percentages in plasma and erythrocyte lipids, and lower phosphatidylcholine and higher sphingomyelin or phosphatidylethanolamine levels in HDL2b and HDL3. The higher HDL cholesterol levels in the plasma of the coastline Chukot residents appears to reflect the higher cholesterol-scavenging capacity of their HDL.

We conclude from this study that the regular consumption of dietary n−3 polyunsaturated fatty acids by the coastline Chukot residents decreased LDL cholesterol transfer from plasma to peripheral cells, and enhanced cholesterol efflux from cellular membranes toward HDL.

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Abbreviations

Apo A-I:

apolipoprotein A-I

apo B:

apolipoprotein B

Chol:

cholesterol

HDL:

high density lipoproteins

LDL:

low density lipoproteins

MUFA:

monounsaturated fatty acids

PC:

phosphatidylcholine

PE:

phosphatidylethanolamine

PL:

phospholipids

P/S:

polyunsaturated fatty acid to saturated fatty acid ratio

PUFA:

polyunsaturated fatty acids

SEM:

standard error of the mean

SPH:

sphingomyelin

TLC:

thin-layer chromatography

TG:

triglycerides

VLDL:

very low density lipoproteins

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Authors and Affiliations

  1. Department of Biochemistry, Institute of Noncommunicable Disease Prevention of the USSR Research Centre for Preventive Medicine, 10, Petroverigsky Str., 101953, Moscow, USSR

    E. Gerasimova, N. Perova, I. Ozerova, V. Polessky, V. Metelskaya & I. Sherbakova

  2. Institute of Nutrition, 109240, Moscow, USSR

    M. Levachev & S. Kulakova

  3. Institute of Therapy, 630003, Novosibirsk, USSR

    Yu. Nikitin & T. Astakhova

Authors
  1. E. Gerasimova
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  2. N. Perova
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  3. I. Ozerova
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  4. V. Polessky
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  5. V. Metelskaya
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  6. I. Sherbakova
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  7. M. Levachev
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  8. S. Kulakova
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  9. Yu. Nikitin
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  10. T. Astakhova
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Gerasimova, E., Perova, N., Ozerova, I. et al. The effect of dietary n−3 polyunsaturated fatty acids on HDL cholesterol in Chukot residentsvs muscovites. Lipids 26, 261–265 (1991). https://doi.org/10.1007/BF02537134

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  • DOI: https://doi.org/10.1007/BF02537134

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