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Linoleoyl-enriched triacylglycerol species increase in maternal liver during late pregnancy in the rat

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Lipids

Abstract

In view of the previously reported changes in the fatty acid composition of maternal liver triacylglycerols in late pregnancy, changes in the composition of maternal liver triacylglycerol species were assessed in rats fed a semipurified diet during pregnancy. Between day 18 and day 21 of pregnancy, total maternal liver triacylglycerols increased by 50%. Triacylglycerol species with a total acyl carbon number (C) of 50 or 60 (C50, C60) remained unchanged while C48 and C52–C58 were relatively increased. The individual triacylglycerol species containing one, two or three linoleoyl moieties were incompletely recovered using a polar high temperature gas-liquid chromatography (GLC) column. Nevertheless, at day 21 compared to day 18, the linoleoyl-containing species were relatively increased by 62–463%, while tripalmitin was decreased by 38%. Our data suggest that despite an adequate intake of linoleic acid (25 g/kg in the diet), maternal hepatic triacylglycerol content of linoleic acid decreased during mid-pregnancy but increased significantly toward term possibly in preparation for the transfer of linoleic acid to the neonate during lactation.

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Abbreviations

BHT:

butylated hydroxytoluene

C:

triacylglycerol total acyl carbon number

EFA:

essential fatty acid(s)

GLC:

gas-liquid chromatography

TG:

triacylglycerol

TLC:

thin-layer chromatography

LLL:

trilinoleoyl glycerol

MLO:

myristoyl linoleoyl oleoyl glycerol

MPO:

myristoyl palmitoyl oleoyl glycerol

MSP:

myristoyl stearoyl palmitoyl glycerol

OLL:

dilinoleoyl oleoyl glycerol

OLO:

dioleoyl linoleyl glycerol

OOO:

trioleoyl glycerol

PLL:

dilinoleoyl palmitoyl glycerol

PLO:

palmitoyl linoleoyl oleoyl glycerol

PLP:

dipalmitoyl linoleoyl glycerol

PLPo:

palmitoyl linoleoyl palmitoleoyl glycerol

POO:

dioleoyl palmitoyl glycerol

PoOO:

dioleoyl palmitoleoyl glycerol

POP:

dipalmitoyl oleoyl glycerol

POPo:

palmitoyl oleoyl palmitoleoyl glycerol

POS:

palmitoyl oleoyl stearoyl glycerol

PPP:

tripalmitoyl glycerol

PPoPo:

dipalmitoleoyl palmitoyl glycerol

PPPo:

dipalmitoyl palmitoleoyl glycerol

PSL:

palmitoyl stearoyl linoleoyl glycerol

PSP:

dipalmitoyl stearoyl glycerol

PSPo:

palmitoyl palmitoleoyl stearoyl glycerol

SLL:

dilinoleoyl stearoyl glycerol

SLO:

stearoyl linoleoyl oleoyl glycerol

SOO:

dioleoyl stearoyl glycerol

SSL:

distearoyl linoleoyl glycerol

SSP:

distearoyl palmitoyl glycerol. (The sequence of letters used does not imply a specific positional order.)

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Authors and Affiliations

  1. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, M5S 1A8, Toronto, Ontario, Canada

    Zhen-Yu Chen, Jilin Yang, Chantale R. Menard & Stephen C. Cunnane

Authors
  1. Zhen-Yu Chen
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  2. Jilin Yang
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  3. Chantale R. Menard
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  4. Stephen C. Cunnane
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Chen, ZY., Yang, J., Menard, C.R. et al. Linoleoyl-enriched triacylglycerol species increase in maternal liver during late pregnancy in the rat. Lipids 27, 21–24 (1992). https://doi.org/10.1007/BF02537053

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  • DOI: https://doi.org/10.1007/BF02537053

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