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Effects of dietary oil related to the toxic oil syndrome on the lipids of guinea pig liver microsomes

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Lipids

Abstract

The potential effects of oil specimens related to cases of toxic oil syndrome (TOS) on the liver microsomal lipid composition from guinea pigs were investigated. For four weeks, animals were fed diets supplemented with either “case oil” (oil related to cases of TOS) or “control oil” (oil unrelated to cases of TOS), either previously heated or not. Results were compared with those from guinea pigs fed the same diet with no oil. The administration of case oil produced changes in liver microsomal lipid composition. Statistically significant differences were also found between heated case and heated control oils. The cholesterol/phospholipid molar ratios and the major phospholipid class distribution were unaffected under these diet conditions. However, increases in the relative contents of linoleic and arachidonic acids and, simultaneously, a reduction in palmitic and palmitoleic acid levels were observed by diet effects. Heated oil administration decreased the saturated/unsaturated ratios in all cases. Our data suggest that changes observed in the fatty acid composition are attributable to the free fatty acid contents of administered oils. The toxic constituents of case oil seem to be able to alter the liver microsomal lipid composition.

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Abbreviations

MUFA:

monounsaturated fatty acid

PUFA:

polyunsaturated fatty acid

SFA:

saturated fatty acid

TOS:

toxic oil syndrome

UFA:

total unsaturated fatty acid

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Authors and Affiliations

  1. Departamento de Bioquímica y Biología Molecular, Universidad de Salamanca, Edificio Departamental, Avda. Compo Charro s/n, 37007, Salamanca, Spain

    E. de la Casa, N. Pérez-González, C. Sánchez-Bernal & M. Llanillo

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  1. E. de la Casa
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  2. N. Pérez-González
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  3. C. Sánchez-Bernal
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  4. M. Llanillo
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de la Casa, E., Pérez-González, N., Sánchez-Bernal, C. et al. Effects of dietary oil related to the toxic oil syndrome on the lipids of guinea pig liver microsomes. Lipids 30, 575–579 (1995). https://doi.org/10.1007/BF02537033

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  • DOI: https://doi.org/10.1007/BF02537033

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