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Lipids

, Volume 30, Issue 12, pp 1111–1118 | Cite as

Effect of marine oils supplementation on coagulation and cellular activation in whole blood

  • Bjarne Østerud
  • Edel Elvevoll
  • Harald Barstad
  • Jan Brox
  • Hanne Halvorsen
  • Karin Lia
  • Jan Ole Olsen
  • Ragnar L. Olsen
  • Charlotte Sissener
  • Øystein Rekdal
  • Eva Vognild
Article

Abstract

A study was performed to explore the effects of supplemental intake of various marine oils known to be part of the Eskimo diet. Healthy men and women (134) were randomly selected to consume 15 mL/d of oil from blubber of seal, cod liver, seal/cod liver, blubber of Minke whale, or no oil for ten weeks. Total cholesterol was unchanged in the oil groups, whereas high density lipoprotein cholesterol increased 7% in the seal/cod liver oil (CLO) group (P<0.05) and 11% in the whale oil group (P<0.005). Triacylglycerol was significantly reduced in the CLO group only. The concentration of prothrombin fragment 1+2 was reduced 25% (P<0.05) after whale oil supplementation. No change in fibrinogen or factor VIIc was detected. Tumor necrosis factor generation in lipopolysaccharide (LPS)-stimulated blood was 30% reduced after whale oil (P<0.05), but was unaffected by intake of seal or CLO. The LPS-induced tissue factor activity in monocytes was reduced to a significant degree only in the seal/CLO group (34%) and whale oil group (35%) (P<0.05). The most dramatic change in thromboxane B2 in LPS-stimulated blood was seen after whale oil intake with 44% reduction (P<0.01). Supplementation of a regular diet with a combination of seal oil and CLO and especially with whale oil seems to have beneficial effects on several products thought to be associated with cardiovascular and thrombotic diseases.

Keywords

Tissue Factor Minke Whale Harp Seal Tissue Factor Activity Tumor Necrosis Factor Generation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CLO

cod liver oil

CV

coefficient of variation

DHA

docosahexaenoic acid

EPA

eicosapentaenoic acid

FVIIc

factor VII coagulant activity

F1+2

prothrombin fragment 1+2

HDL

high density lipoprotein

LPS

lipopolysaccharide

PAEF

platelet activating factor

PDGF

platelet derived growth factor

PUFA

polyunsaturated fatty acids

TF

tissue factor

TG

triacylglycerol

TNF

tumor necrosis factor

TxA

thromboxane A

TxB

thromboxane B

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Copyright information

© American Oil Chemists’ Society 1995

Authors and Affiliations

  • Bjarne Østerud
    • 1
  • Edel Elvevoll
    • 3
  • Harald Barstad
    • 3
  • Jan Brox
    • 4
  • Hanne Halvorsen
    • 1
  • Karin Lia
    • 1
  • Jan Ole Olsen
    • 1
  • Ragnar L. Olsen
    • 3
  • Charlotte Sissener
    • 1
  • Øystein Rekdal
    • 2
  • Eva Vognild
    • 1
  1. 1.Department of Biochemistry, Institute of Medical BiologyUniversity of TromsøTromsøNorway
  2. 2.Department of Biotechnology, Institute of Medical BiologyUniversity of TromsøTromsøNorway
  3. 3.Norwegian Institute of Fisheries and Aquaculture Ltd.TromsøNorway
  4. 4.Hammerfest HospitalHammerfestNorway

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