Skip to main content

Advertisement

SpringerLink
Log in

Immunoregulatory functions of paf-acether. VI. Dual effect on human B cell proliferation

  • Cell Biology of PAF
  • Published:
Lipids

Abstract

The role of paf-acether (paf), a phospholipid cytokine, in the modulation of human B cell function was investigated. Paf, from 1×10−5 M to 10−6 M, decreased B cell proliferation induced by both phorbol myristate acetate (PMA) and anti-IgM antibodies (anti-IgM Ab). By contrast, 1×10−7 M to 1×10−9 M paf enhanced PMA triggered, but not anti-IgM triggered B cell proliferation. B cell proliferation was modulated between 24 and 72 hr of culture indicating that the effect of paf did not merely reflect a shift in proliferation kinetics. Interestingly, paf also enhanced the spontaneous proliferation of a Burkitt lymphoma-derived B cell line, Raji, which suggests that paf can directly act on B cells. The modulatory effect of paf on peripheral blood B cells was independent of PMA concentration, yet the effect on Raji cells was dependent upon cell density. The data suggest that paf is a potent modulator of B cell function, and may be involved in the control of humoral immune response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

anti-IgM Ab:

anti-IgM antibodies

EBV:

Epstein-Barr virus

FCS:

fetal calf serum

HSA:

human serum albumin

IL:

interleukin

paf:

paf-acether, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine

PHA:

phytohemagglutinin A

PKC:

protein kinase C

PMA:

phorbol myristate acetate

TNF:

tumor necrosis factor

References

  1. Cambier, J.C., Justement, L.B., Newell, M.K., Chen, Z.Z., Harris, L.K. Sandoval, V.M., Klemsz, M.J., and Ransom, J.T. (1987)Immunol. Rev. 95, 37–51.

    Article  PubMed  CAS  Google Scholar 

  2. Kishimoto, T., and Hirano, T. (1988)Annu. Rev. Immunol. 6, 485–512.

    Article  PubMed  CAS  Google Scholar 

  3. O'Garra, A., Umland, S., DeFrance, T., and Christiansen, J. (1988)Immunology. Today 9, 45–51.

    Article  PubMed  Google Scholar 

  4. Sharma, S., Mehta, S.R., and Ford, R.J. (1987)Lymphokine Research 6, 245–255.

    PubMed  CAS  Google Scholar 

  5. Monroe, J.G., and Kass, M.J. (1985)J. Immunol. 135, 1674–1679.

    PubMed  CAS  Google Scholar 

  6. Ransom, J.T., Harris, L.K., and Cambier, J.C. (1986)J. Immunol. 137, 708–713.

    PubMed  CAS  Google Scholar 

  7. Chen, Z.Z., Coggeshall, K.M., and Cambier, J.C. (1986)J. Immunol. 136, 2300–2304.

    PubMed  CAS  Google Scholar 

  8. Dugas, B., Vazquez, A., Klein, B., Delfraissy, J.F., Rannou, M.T. Gérard, J.P., and Galanaud, P. (1986)Eur. J. Immunol. 16, 1609–1614.

    PubMed  CAS  Google Scholar 

  9. Rudich, S.M., Roux, K.H., Winchester, R.J., and Mongini, P.K.A. (1988)J. Exp. Med. 168, 247–266.

    Article  PubMed  CAS  Google Scholar 

  10. Suzuki, T., Butler, J.L., and Cooper, M.D. (1985)J. Immunol. 134, 2470–2476.

    PubMed  CAS  Google Scholar 

  11. Benveniste, J., Henson, P.M., and Cochrane, C.G. (1972)J. Exp. Med. 136, 1356–1377.

    Article  PubMed  CAS  Google Scholar 

  12. Wardlow, A.J., Moqbel, R., Cromwell, O., and Kay, A.B. (1986)J. Clin. Invest. 78, 1701–1707.

    Google Scholar 

  13. Valone, F.H., Philip, R., and Debs, R.D. (1988)Immunology 64, 715–722.

    PubMed  CAS  Google Scholar 

  14. Vivier, E., Salem, P., Dulioust, A., Metezeau, P., Benveniste, J., and Thomas, Y. (1988)Eur. J. Immunol. 18, 425–430.

    PubMed  CAS  Google Scholar 

  15. Dulioust, A., Vivier, E., Salem, P., Benveniste, J., and Thomas, Y. (1988)J. Immunol. 140, 240–245.

    PubMed  CAS  Google Scholar 

  16. Rola-Pleszczynski, M., Pouliot, C., Turcotte, S., Pignol, B., Braquet, P., and Bouvrette, L. (1988)J. Immunol. 140, 3547–3552.

    PubMed  CAS  Google Scholar 

  17. Vivier, E., Deryckx, S., Wang, J.L., Valentin, H., Peronne, C., De Vries, J.E., Bernard, A., Benveniste, J., and Thomas, Y. (1990)International Immunol. 2, 545–551.

    Article  CAS  Google Scholar 

  18. Salem, P., Deryckx, S., Dulioust, A., Vivier, E., Denizot, Y., Damais, C., Dinarello, C.A., and Thomas, Y. (1990)J. Immunol. 144, 1338–1345.

    PubMed  CAS  Google Scholar 

  19. Dubois, C., Bissonnette, E., and Rola-Pleszczynski, M. (1989)J. Immunol. 143, 964–970.

    PubMed  CAS  Google Scholar 

  20. Bussolino, F., Foa, R., Malavasi, F., Ferrando, M.L., and Camussi, G. (1984)Exp. Hematol. 12, 688–693.

    PubMed  CAS  Google Scholar 

  21. Foa, R., Bussolino, F., Ferrando, M.L., Guarini, A., Tetta, C. Mazzone, R., Gugliotta, L., and Camussi, G. (1985)Cancer Res. 45, 4483–4485.

    PubMed  CAS  Google Scholar 

  22. Yssel, H., De Vries, J.E., Koken, M., Van Blitterswijk, W., and Spits, H.J. (1984)J. Immunol. Methods 72, 219–224.

    Article  PubMed  CAS  Google Scholar 

  23. Thiele, D.L., and Lipsky, P.E. (1985)J. Immunol. 134, 786–790.

    PubMed  CAS  Google Scholar 

  24. Blank, M.L., Lee, T.-c., Fitzgerald, V., and Snyder, F. (1981)J. Biol. Chem. 256, 175–178.

    PubMed  CAS  Google Scholar 

  25. Richard, Y., Leprince, C., Dugas, B., Treton, D., and Galanaud, P. (1987)J. Immunol. 139, 1563–1567.

    PubMed  CAS  Google Scholar 

  26. Falcoff, R.J.M., Muraguchi, A., Hong, J.X., Butler, J.L., Dinarello, C.A., and Fauci, A.S. (1983)J. Immunol. 131, 801–806.

    Google Scholar 

  27. Kerhl, J.H., Miller, A., and Fauci, A.S. (1987)J. Exp. Med. 166, 786–791.

    Article  Google Scholar 

  28. Dulioust, A., Duprez, V., Pitton, C., Salem, P., Hemar, A., Benveniste, J., and Thomas, Y. (1990)J. Immunol. 144, 3123–3129.

    PubMed  CAS  Google Scholar 

  29. Dugas, B., Kolb, J.P., Klein, B., Braquet, P., and Mencia-Huerta, J.M. (1989) Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, Tokyo (Japan), p. 176 (Abstract No. 17).

  30. Gay, J.C., and Stitt, E.S. (1988)Blood 71, 159–165.

    PubMed  CAS  Google Scholar 

  31. O'Flaherty, J.T., and Nishihira, J. (1987)J. Immunol. 138, 1889–1895.

    PubMed  Google Scholar 

  32. Gay, J.C., and Stitt, E.S. (1988)J. Cell. Physiol. 137, 439–447.

    Article  PubMed  CAS  Google Scholar 

  33. Vandenabeele, P., Jayaram, B., Devos, R., Shaw, A., and Fiers, W. (1988)Eur. J. Immunol. 18, 1027–1032.

    PubMed  CAS  Google Scholar 

  34. Pistoia, V., Cozzolino, F., Rubartelli, A., Torcia, M., Roncella, S., and Ferrarini, M. (1986)J. Immunol. 136, 1688–1692.

    PubMed  CAS  Google Scholar 

  35. Sung, S.S.J., Jung, L.K.L., Walters, J.A., Jeffes III, E.W.B., Granger, G.A., and Fu, S.M. (1989)J. Clin. Invest. 84, 236–243.

    PubMed  CAS  Google Scholar 

  36. Yee, C., Biondi, A., Wang, X.H., Iscove, N.N., De Sousa, J., Aarden, L.A., Wong, G.G., Clark, S.C., Messner, H.A., and Minden, M.D. (1989)Blood 74, 798–804.

    PubMed  CAS  Google Scholar 

  37. Klein, B., Zhang, X.G., Jourdan, M., Content, J., Houssiau, F., Aarden, L.A., Piechaczyk, M., and Bataille, R. (1989)Blood 73, 517–526.

    PubMed  CAS  Google Scholar 

  38. Dugas, B., Mencia-Huerta, J.M., and Braquet, P. (1989) Taipei Satellite Symposium of the 3rd International Conference on Platelet Activating Factor (PAF), Taipei (ROC), Abstract, p. 20.

  39. Swendeman, S., and Thorley-Lawson, D.A. (1987)EMBO J. 6, 1637–1642.

    PubMed  CAS  Google Scholar 

  40. O'Flaherty, J.T., Surles, J.R., Redman, J., Jacobson, D., Piantadosi, C., and Wykle, R.L. (1986)J. Clin. Invest. 78, 381–388.

    PubMed  Google Scholar 

  41. Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamoto, T., and Shimizu, T. (1991)Nature 349, 342–346.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire d'Immunopathologie et d'Immunologie Virale, Institut National de la Santé et de la Recherche Médicale, U131, Universite Paris-Sud, 92140, Clamart, France

    Corinne Leprince, Dominique Treton, Pierre Galanaud & Yolande Richard

  2. Laboratoire d'Immunopharmacologie de l'Allergie et de l'Inflammation, Institut National de la Santé et de la Recherche Médicale, U200, Université Paris-Sud, 32 rue des Carnets, Clamart, France

    Eric Vivier, Jacques Benveniste & Yolene Thomas

Authors
  1. Corinne Leprince
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric Vivier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dominique Treton
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pierre Galanaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jacques Benveniste
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yolande Richard
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yolene Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Leprince, C., Vivier, E., Treton, D. et al. Immunoregulatory functions of paf-acether. VI. Dual effect on human B cell proliferation. Lipids 26, 1204–1208 (1991). https://doi.org/10.1007/BF02536532

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02536532

Keywords

Search

Navigation