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Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor

  • Cell Biology of PAF
  • Review
  • Published:
Lipids

Abstract

In a variety of stimulated cells, platelet-activating factor (PAF) and numerous arachidonate derivatives are coproducts that form as a consequence of receptor-mediated phospholipid mobilization. These lipid co-products produce a plethora of biological effects in a wide variety of cell systems. Furthermore, they often have a fascinating, although less widely appreciated, interaction. 5-HETE, at submicromolar concentrations, exerts relatively few direct bioactions. It does, however, potently (16–160 nM) raise cytosolic free calcium [Ca2+]i and augment PAF-induced responses in human polymorphonuclear neutrophils (PMN) by as much as 100- to 1000-fold. 5-HETE acts on PMN by a structurally specific, stereospecific and pertussis toxin-inhibitable mechanism. In addition, PMN exposed to 5-HETE exhibit homologous but not heterologous desensitization. These findings suggest that 5-HETE, like PAF, may bind to its own specific plasmalemmal receptors to exert its unique set of bioactions. However, further investigation is required to demonstrate any putative 5-HETE receptors. Other potential mechanisms of 5-HETE-induced bioactions together with the possible effects of 5-HETE on PAF transduction mechanisms are also discussed.

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Abbreviations

[Ca2+]i :

cytosolic free calcium ions

DAG:

diacylglycerol

G-proteins:

guanine nucleotide-binding proteins

HETE:

hydroxyicosatetraenoate

HPETE:

hydroperoxyicosatetraenoate

IP3 :

inositol 1,4,5-triphosphate

LT:

leukotriene

PAF:

platelet-activating factor

PG:

prostaglandin

PIP2 :

phosphatidylinositol 4,5-bisphosphate

PKC:

protein kinase C

PL:

phospholipase

PMN:

polymorphonuclear neutrophils

R:

receptor

S:

stimulus

TX:

thromboxane

References

  1. Irvine, R.F. (1982)Biochem. J. 204, 3–16.

    PubMed  CAS  Google Scholar 

  2. O'Flaherty, J.T. (1987)Biochem. Pharmacol. 36, 407–412.

    Article  PubMed  Google Scholar 

  3. Berridge, M.J., and Irvine, R.F. (1984)Nature 312, 315–321.

    Article  PubMed  CAS  Google Scholar 

  4. Nishizuka, Y. (1986)Science 233, 305–312.

    Article  PubMed  CAS  Google Scholar 

  5. Abdel-Latif, A.A. (1986)Pharmacol. Rev. 38, 227–272.

    PubMed  CAS  Google Scholar 

  6. Berridge, M.J. (1987)Ann. Rev. Biochem. 56, 159–193.

    PubMed  CAS  Google Scholar 

  7. Gilman, A.G. (1987)Ann. Rev. Biochem. 56, 615–649.

    Article  PubMed  CAS  Google Scholar 

  8. Freissmuth, M., Casey, P.J., and Gilman, A.G. (1989)FASEB J. 3, 2125–2131.

    PubMed  CAS  Google Scholar 

  9. Downes, C.P. (1989)Biochem. Soc. Trans. 17, 259–268.

    PubMed  CAS  Google Scholar 

  10. Wykle, R.L., Olson, S.C., and O'Flaherty, J.T. (1986)Adv. Inflam. Res. 11, 71–81.

    Google Scholar 

  11. Braquet, P., Touqui, L., Shen, T.Y., and Vargaftig, B.B. (1987)Pharmacol. Rev. 39, 97–145.

    PubMed  CAS  Google Scholar 

  12. Snyder, F. (1989)Proc. Soc. Exp. Biol. Med. 190, 125–135.

    PubMed  CAS  Google Scholar 

  13. Samuelsson, B. (1983)Science 220, 568–575.

    Article  PubMed  CAS  Google Scholar 

  14. O'Flaherty, J.T. (1982)Lab. Invest. 47, 314–329.

    PubMed  Google Scholar 

  15. Piper, P.J. (1984)Physiol. Rev. 64, 744–761.

    PubMed  CAS  Google Scholar 

  16. Vanderhoek, J.Y. (1985) inBiochemistry of Arachidonic Acid Metabolism (Lands, W.E.M., ed.) Ch. 13, pp. 213–226, Martinus Nijhoff Publishing, Boston.

    Google Scholar 

  17. Spector, A.A., Gordon, J.A., and Moore, S.A. (1988)Prog. Lipid Res. 27, 271–323.

    Article  PubMed  CAS  Google Scholar 

  18. Samuelsson, B., Dahlen, S-E., Lindgren, J., Rouzer, C.A., and Serhan, C.N. (1987)Science 237, 1171–1176.

    Article  PubMed  CAS  Google Scholar 

  19. Barnes, P.J., Chung, K.F., and Page, C.P. (1988)Pharmacol. Rev. 40, 49–84.

    PubMed  CAS  Google Scholar 

  20. Belch, J.J.F. (1989)Prostaglandins Leukotrienes and Essential Fatty Acids 36, 219–234.

    Article  CAS  Google Scholar 

  21. Nishihira, J., and Ishibashi, T. (1986)Lipids 21, 780–785.

    Article  PubMed  CAS  Google Scholar 

  22. Okayasu, T., Hoshii, K., Seyama, K., Ishibashi, T., and Iami, Y. (1986)Biochim. Biophys. Acta 876, 58–64.

    PubMed  CAS  Google Scholar 

  23. Wykle, R.L., Kraemer, W.F., and Schremmer, J.M. (1980)Biochim. Biophys. Acta 619, 58–67.

    PubMed  CAS  Google Scholar 

  24. Kawasaki, T., and Snyder, F. (1987)Biochim. Biophys. Acta 920, 85–93.

    PubMed  CAS  Google Scholar 

  25. Valone, F.H., Coles, E., Reinhold, V.R., and Goetzl, E.J. (1982)J. Immunol. 129, 1637–1641.

    PubMed  CAS  Google Scholar 

  26. Hwang, S-B., Lee, C-S.C., Cheah, M.J., and Shen, T.Y. (1983)Biochemistry 22, 4756–4763.

    Article  PubMed  CAS  Google Scholar 

  27. O'Flaherty, J.T., Surles, J.R., Redman, J., Jacobson, D., Piantadosi, C., and Wykle, R.L. (1986)J. Clin. Invest. 78, 381–388.

    PubMed  Google Scholar 

  28. Lapetina, E.G. (1982)J. Biol. Chem. 257, 7314–7317.

    PubMed  CAS  Google Scholar 

  29. Shulka, S.D., and Hanahan, D.J. (1982)Biochem. Biophys. Res. Commun. 106, 697–703.

    Article  Google Scholar 

  30. Mauco, G., Chap, H., and Douste-Blazy, L. (1983)FEBS Letters 153, 361–365.

    Article  PubMed  CAS  Google Scholar 

  31. MacIntyre, D.E., and Pollock, W.K. (1983)Biochem. J. 212, 433–437.

    PubMed  CAS  Google Scholar 

  32. Rossi, A.G., McMillan, R.M., and MacIntyre, D.E. (1988)Agents and Actions 24, 272–282.

    Article  PubMed  CAS  Google Scholar 

  33. Chilton, F.H., O'Flaherty, J.T., Walsh, C.E., Thomas, M.J., Wykle, R.L., DeChatelet, L.R., and Waite, B.M. (1982)J. Biol. Chem. 257, 5402–5407.

    PubMed  CAS  Google Scholar 

  34. Lin, A.H., Morton, D.R., and Gorman, R.R. (1982)J. Clin. Invest. 70, 1058–1065.

    PubMed  CAS  Google Scholar 

  35. Lad, P.M., Olson, C.V., and Grewal, I.S. (1985)Biochem. Biophys. Res. Commun. 129, 632–638.

    Article  PubMed  CAS  Google Scholar 

  36. Naccache, P.H., Molski, M.M., Volpi, M., Becker, E.L., and Sha'afi, R.I. (1985)Biochem. Biophys. Res. Commun. 130, 677–684.

    Article  PubMed  CAS  Google Scholar 

  37. Naccache, P.H., Molski, M.M., Volpi, M., Shefcyk, J., Molski, T.F.P., Loew, L., Becker, E.L., and Sha'afi, R.I. (1986)J. Leukocyte Biol. 40, 533–548.

    PubMed  CAS  Google Scholar 

  38. Houslay, M.D., Bojanic, D., and Wilson, A. (1986)Biochem. J. 234, 737–740.

    PubMed  CAS  Google Scholar 

  39. Verghese, M.W., Charles, L., Jakoi, L., Dillon, S.B., and Snyderman, R. (1987)J. Immunol. 138, 4374–4380.

    PubMed  CAS  Google Scholar 

  40. Valone, F.H. (1987)Thromb. Res. 45, 427–435.

    Article  PubMed  CAS  Google Scholar 

  41. Doebber, T.W., and Wu, M.S. (1987)Proc. Natl. Acad. Sci. USA 84, 7557–7561.

    Article  PubMed  CAS  Google Scholar 

  42. Tessner, T.G., O'Flaherty, J.T., and Wykle, R.L. (1989)J. Biol. Chem. 264, 4794–4799.

    PubMed  CAS  Google Scholar 

  43. Johnson, M., Carey, F., and MacMillan, R.M. (1983)Essays Biochem. 19, 40–141.

    PubMed  CAS  Google Scholar 

  44. Yamamoto, S. (1989)Prostaglandins, Leukotrienes and Essential Fatty Acids 35, 219–229.

    Article  CAS  Google Scholar 

  45. Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., Shipley, M.E., and Smith, M.J.H. (1980)Nature 286, 264–265.

    Article  PubMed  CAS  Google Scholar 

  46. Bray, M.A. (1983)Br. Med. Bull. 39, 249–254.

    PubMed  CAS  Google Scholar 

  47. Sirois, P., Borgeat, P., Jeanson, A., Roy, S., and Girard, G. (1980)Prostaglandins Med. 5, 429–444.

    Article  PubMed  CAS  Google Scholar 

  48. Sirois, P., Borgeat, P., and Jeanson, A. (1981)J. Pharm. Pharmacol. 33, 466–468.

    PubMed  CAS  Google Scholar 

  49. Sirois, P., Roy, S., and Borgeat, P. (1981)Prostaglandins Med. 6, 153–159.

    Article  PubMed  CAS  Google Scholar 

  50. Goldman, D.W., and Goetzl, E.J. (1982)J. Immunol. 129, 1600–1604.

    PubMed  CAS  Google Scholar 

  51. Kreisle, R.A., and Parker, C.W. (1983)J. Exp. Med. 157, 628–641.

    Article  PubMed  CAS  Google Scholar 

  52. Goldman, D.W., and Goetzl, E.J. (1984)J. Exp. Med. 159, 1027–1041.

    Article  PubMed  CAS  Google Scholar 

  53. O'Flaherty, J., Kosfeld, S., and Nishihira, J. (1986)J. Cell. Physiol. 126, 359–370.

    Article  PubMed  Google Scholar 

  54. Stenson, W.F., and Parker, C.W. (1979)J. Clin. Invest. 64, 1457–1465.

    PubMed  CAS  Google Scholar 

  55. Bonser, R.W., Siegel, M.I., Chung, S.M., McConnell, R.T., and Cuatrecasas, P. (1981)Biochemistry 20, 5297–5301.

    Article  PubMed  CAS  Google Scholar 

  56. Bonser, R.W., Siegel, M.I., McConnell, R.T., and Cuatrecasas, P. (1981)Biochem. Biophys. Res. Commun. 102, 1269–1275.

    Article  PubMed  CAS  Google Scholar 

  57. O'Flaherty, J.T., Wykle, R.L., Redman, J., Samuel, M., and Thomas, M. (1986)J. Immunol. 137, 3277–3283.

    PubMed  Google Scholar 

  58. Powell, W.S. (1984)J. Biol. Chem. 259, 3082–3089.

    PubMed  CAS  Google Scholar 

  59. Hansson, G., Lindgren, J.A., Dahlen, S-E., Hedqvist, P., and Samuelsson, B. (1981)FEBS Letters 130, 107–112.

    Article  PubMed  CAS  Google Scholar 

  60. Camp, R.D.R., Woollard, P.M., Mallet, A.I., Fincham, N.J., Ford-Hutchinson, A.W., and Bray, M.A. (1982)Prostaglandins 23, 631–641.

    Article  PubMed  CAS  Google Scholar 

  61. Jubiz, W., Radmark, O., Malmsten, C., Hansson, G., Lindgren, J.A., Palmblad, J., Uden, A.-M., and Samuelsson, B. (1982)J. Biol. Chem. 257, 6196–6110.

    Google Scholar 

  62. Naccache, P.H., Molski, T.F.P., Becker, E.L., Borgeat, P., Picard, S., Vallerand, P., and Sha'afi, R.I. (1982)J. Biol. Chem. 257, 8608–8611.

    PubMed  CAS  Google Scholar 

  63. Granstrom, E., and Kumlin, M. (1987) inProstaglandins and Related Substances (Benedetto, C., McDonald-Gibson, R.G., Nigam, S., and Slater, T.F., eds.) Ch. 2, pp. 5–27, IRL Press, Oxford, England.

    Google Scholar 

  64. Palmer, R.M.J., Stepney, R.J., Higgs, G.A., and Eakins, K.E. (1980)Prostaglandins 20, 411–418.

    Article  PubMed  CAS  Google Scholar 

  65. Goetzl, E.J., Brash, A.R., Tauber, A.I., Oates, J.A., and Hubbard, W.C. (1980)Immunol. 39, 491–501.

    CAS  Google Scholar 

  66. Goetzl, E.J., and Pickett, W.C. (1980)J. Immunol. 125, 1789–1791.

    PubMed  CAS  Google Scholar 

  67. Goetzl, E.J., Weller, P.F., and Sun, F.F. (1980)J. Immunol. 124, 926–933.

    PubMed  CAS  Google Scholar 

  68. Konig, W., KRoegel, C., Kunau, H.W., and Borgeat, P. (1981)Int. Archs. Allergy Appl. Immun. 66, 168–171.

    Google Scholar 

  69. Stenson, W.F., and Parker, C.W. (1980)J. Immunol. 124, 2100–2104.

    PubMed  CAS  Google Scholar 

  70. Bokoch, G.M., and Reed, P.W. (1981)J. Biol. Chem. 256, 5317–5320.

    PubMed  CAS  Google Scholar 

  71. O'Flaherty, J.T., Thomas, M.J., Lees, C.J., and McCall, C.E. (1981)Am. J. Pathol. 104, 55–62.

    PubMed  Google Scholar 

  72. Bass, D.A., Thomas, M.J., Goetzl, E.J., DeChatelet, L.R., and McCall, C.E. (1981)Biochem. Biophys. Res. Commun. 100, 1–7.

    Article  PubMed  CAS  Google Scholar 

  73. Thomas, M.J., O'Flaherty, J.T., Cousart, S., and McCall, C.E. (1982)Prostaglandins 23, 265–272.

    Article  PubMed  CAS  Google Scholar 

  74. Copas, J.L., Borgeat, P., and Gardiner, P.J. (1982)Prostaglandins Leukotrienes Med. 8, 105–114.

    Article  CAS  Google Scholar 

  75. Yamamoto, S., Ishii, M., Nakadate, T., Nakaki, T., and Kato, R. (1983)J. Biol. Chem. 258, 12149–12152.

    PubMed  CAS  Google Scholar 

  76. Naor, Z., Vanderhoek, J.Y., Lindner, H.R., and Catt, K.J. (1983) inAdvances in Prostaglandin, Thromboxane and Leukotriene Research (Samuelsson, B., Paoletti, R., and Ramwell, P., eds.) Vol. 12, pp. 259–263, Raven Press, New York.

    Google Scholar 

  77. Shelhamer, J.H., Marom, Z., Sun, F., Bach, M.K., and Kaliner, M. (1982)Chest 81, 36S-37S.

    Google Scholar 

  78. Stenson, W.F., and Lobos, E. (1981)Gastroenterology 80, 1293.

    Google Scholar 

  79. Musch, M.W., Miller, R.J., Field, M., and Siegel, M.I. (1982)Science 217, 1255–1256.

    Article  PubMed  CAS  Google Scholar 

  80. Naccache, P.H., Sha'afi, R.I., Borgeat, P., and Goetzl, E.J. (1981)J. Clin. Invest. 67, 1584–1587.

    PubMed  CAS  Google Scholar 

  81. O'Flaherty, J.T., and Nishihira, J. (1987)Biochem. Biophys. Res. Commun. 148, 575–581.

    Article  PubMed  Google Scholar 

  82. O'Flaherty, J.T., Jacobson, D., and Redman, J. (1988)J. Immunol. 140, 4323–4328.

    PubMed  Google Scholar 

  83. Rossi, A.G., Thomas, M.J., and O'Flaherty, J.T. (1988)FEBS Letters 240, 163–166.

    Article  PubMed  CAS  Google Scholar 

  84. O'Flaherty, J.T., Thomas, M.J., Hammett, M.J., Carroll, C., McCall, C.E., and Wykle, R.L., (1983)Biochem. Biophys. Res. Commun. 111, 1–7.

    Article  PubMed  Google Scholar 

  85. O'Flaherty, J.T., Schmitt, J.D., and Wykle, R.L. (1985)Biochem. Biophys. Res. Commun. 127, 916–923.

    Article  PubMed  Google Scholar 

  86. O'Flaherty, J.T., Thomas, M.J., McCall, C.E., and Wykle, R.L. (1983)Res. Commun. Chem. Pathol. Pharmacol. 40, 475–487.

    PubMed  Google Scholar 

  87. O'Flaherty, J.T., Wykle, R.L., Thomas, M.J., and McCall, C.E. (1984)Res. Commun. Chem. Pathol. Pharmacol. 43, 3–23.

    PubMed  Google Scholar 

  88. O'Flaherty, J.T. (1985)J. Cell. Physiol. 122, 229–239.

    Article  PubMed  Google Scholar 

  89. O'Flaherty, J.T., and Nishihira, J. (1987)J. Immunol. 138, 1889–1895.

    PubMed  Google Scholar 

  90. O'Flaherty, J.T., and Nishihira, J. (1987)Advances in the Biosciences 66, 251–253.

    Google Scholar 

  91. O'Flaherty, J.T. (1988) inProstaglandins: Biology and Chemistry of Prostaglandins and Related Eicosanoids (Curtis-Prior, P.B., ed.) Ch. 55, pp. 663–670, Churchill Livingstone, Edinburgh, U.K.

    Google Scholar 

  92. O'Flaherty, J.T., and Nishihira, J. (1987) inNew Horizons in Platelet Activating Factor Research (Winslow, C.M., and Lee, M.L., eds.) Ch. 13, pp. 131–136, John Wiley & Sons, Ltd., London.

    Google Scholar 

  93. Saito, H., Hirai, A., Tamura, Y., and Yoshida, S. (1985)Prostaglandins Leukotriene Med. 18, 271–286.

    Article  CAS  Google Scholar 

  94. Billah, M.M., Bryant, R.W., and Siegel, M.I. (1985)J. Biol. Chem. 260, 6899–6906.

    PubMed  CAS  Google Scholar 

  95. Peters, S.P., Siegel, M.I., Kagey-Sobotka, A., and Lichtenstein, L.M. (1981)Nature 292, 455–457.

    Article  PubMed  CAS  Google Scholar 

  96. Peters, S.P., Kagey-Sobotka, A., MacGlashan, D.W., Jr., Siegel, M.I., and Lichtenstein, L.M. (1982)J. Immunol. 129, 797–803.

    PubMed  CAS  Google Scholar 

  97. Stenson, W.F., Parker, C.W., and Sullivan, T.J. (1980)Biochem. Biophys. Res. Commun. 96, 1045–1052.

    PubMed  CAS  Google Scholar 

  98. Siegel, M.I., McConnell, R.T., Bonser, R.W., and Cuatrecasas, P. (1982)Biochem. Biophys. Res. Commun. 104, 874–881.

    Article  PubMed  CAS  Google Scholar 

  99. Malo, P.E. (1989)Prostaglandins 37, 539–551.

    Article  PubMed  CAS  Google Scholar 

  100. Krause, K-H., and Lew, D.P. (1988)Sem. Hematol. 25, 112–122.

    CAS  Google Scholar 

  101. Mexmain, S., Gualde, N., Aldigier, J.C., Motta, C., Chable-Rabinovitch, H. (1984)Prostaglandins Leukotrienes Med. 13, 93–97.

    Article  CAS  Google Scholar 

  102. Rabier, M., Crastes de Paulet, A., and Damon, M. (1988)Biochem. Biophys. Res. Commun. 152, 1179–1184.

    Article  PubMed  CAS  Google Scholar 

  103. Badwey, J.A., Robinson, J.M., Horn, W., Soberman, R.J., Karnovsky, M.J., and Karnovsky, M.L. (1988)J. Biol. Chem. 263, 2779–2786.

    PubMed  CAS  Google Scholar 

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  1. Department of Medicine, Section of Infectious Diseases, Wake Forest University Medical Center, 27103, Winston-Salem, NC

    Adriano G. Rossi & Joseph T. O'Flaherty

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Rossi, A.G., O'Flaherty, J.T. Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor. Lipids 26, 1184–1188 (1991). https://doi.org/10.1007/BF02536528

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