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Involvement of heme components in sterol metabolism ofSaccharomyces cerevisiae

  • Plant and Fungal Sterols: Biosynthesis, Metabolism and Function Papers Presented at a Symposium Held at the AOCS Annual Meeting. Baltimore, MD, April 1990
  • Review
  • Published:
Lipids

Abstract

There is an intimate association between sterol biosynthesis in yeast and aerobicity. Besides the requirement for molecular oxygen for the epoxidation of squalene, cytochrome hemoproteins are involved in demethylation and desaturation steps. Regulatory effects of hemes on sterol formation have been demonstrated using specifically defective mutants of yeast. Heme competency participates in a mechanism whereby wild-type cells are prevented from taking exogenous sterols from the growth media. The multiple interactions of hemes and sterols appear to be associated with the variously defined functions for sterols in the yeast cells.

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Abbreviations

ALA:

δ-aminolevulinic acid

DOS:

dioxidosqualene

HMG-CoA:

3-hydroxy-3-methylglutaryl coenzyme A

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Authors and Affiliations

  1. Department of Microbiology, North Carolina State University, 27695-7615, Raleigh, North Carolina

    R. Todd Lorenz & L. W. Parks

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  1. R. Todd Lorenz
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  2. L. W. Parks
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Lorenz, R.T., Parks, L.W. Involvement of heme components in sterol metabolism ofSaccharomyces cerevisiae . Lipids 26, 598–603 (1991). https://doi.org/10.1007/BF02536423

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  • DOI: https://doi.org/10.1007/BF02536423

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