The experiments reported are part of our effort to dissociate the tumor-enhancing effects of dietary fat and high caloric intake. Rats either were fed ad libitum diets containing 4% corn oil or their calories were restricted by 40% and their diets contained 13.1% corn oil. Incidence of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors was 80% in rats fed ad libitum and 20% in those fed the calorie-restricted diets. Incidence of 1,2-dimethylhydrazine (DMH)-induced colon tumors was 100% in rats fed ad libitum and 53% in those whose caloric intake was restricted by 40%. The tumor yield (tumors per tumor-bearing rat) was significantly lower in rats on caloric restriction. In another series, rats were fed diets containing 5, 15 or 20% corn oil ad libitum or were fed calorie-restricted (by 25%) diets which provided 20 or 26.6% corn oil (therefore, the same absolute amount of fat was consumed in each of the pair-fed groups). Tumor incidence and tumor yield in the two calorie-restricted groups were similar to those seen in the rats fed 5% fat ad lititum; tumor burden (total g of tumor) was 45–65% lower in the calorie-restricted rats. The data suggest that caloric intake is a more stringent determinant of tumor growth than fat intake.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Moreschi, C. (1909)Z Immunitätsforsch. 2, 651–673.
Rous, P. (1910–11)Proc. Soc. Exp. Biol. Med. 8, 128–130.
Bischoff, F., Long, M.L. and Maxwell, L.C. (1935)Am. J. Cancer 24, 549–553.
Sivertsen, I., and Hastings, W.H. (1938)Minnesota Med. 21, 873–875.
Tannenbaum, A. (1940)Am. J. Cancer 38, 335–350.
Tannenbaum, A. (1942)Cancer Res. 2, 460–467.
Tannenbaum, A. (1945)Cancer Res. 5, 609–615.
Tannenbaum, A. (1945)Cancer Res. 5, 616–625.
Lavik, P.S., and Baumann, C.A. (1943)Cancer Res. 3, 749–756.
Kritchevsky, D., Weber, M.M., and Klurfeld, D.M. (1984)Cancer Res. 44, 3174–3177.
Pozharisski, K.M. (1973) inPathology of Tumours in Laboratory Animals (Turusov, V.S., ed.) Vol. I, Part 1, pp. 119–140, IARC, Lyon.
Bernhart, F.W., and Tomarelli, R.M. (1966)J. Nutr. 89, 495–500.
Am. Inst. Nutr. Ad Hoc Committee on Standards for Nutritional Studies (1977)J. Nutr. 107, 1340–1348.
Carroll, K.K., and Khor, H.T. (1971)Lipids, 6, 415–420.
Carroll, K.K., and Khor, H.T. (1970)Cancer Res. 20, 2260–2264.
McCay, C.M., Ellis, G.H., Barnes, L.L., Smith, C.A.H., and Sperling, G. (1939)J. Nutr. 18, 15–25.
Carlson, A.J., and Hoelzel, F. (1946)J. Nutr. 31, 363–375.
Ross, M.H., and Bras, G. (1971)J. Natl. Cancer Inst. 47, 1095–1113.
About this article
Cite this article
Kritchevsky, D., Weber, M.M., Buck, C.L. et al. Calories, fat and cancer. Lipids 21, 272–274 (1986). https://doi.org/10.1007/BF02536411
- Caloric Restriction
- Tumor Incidence
- Restricted Diet
- Final Body Weight