• Papers from the Brian L. Walker Memorial Symposium on Lipids and Cancer Presented at the 76th AOCS Annual Meeting in Philadelphia, Pennsylvania, May 1985
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Calories, fat and cancer


The experiments reported are part of our effort to dissociate the tumor-enhancing effects of dietary fat and high caloric intake. Rats either were fed ad libitum diets containing 4% corn oil or their calories were restricted by 40% and their diets contained 13.1% corn oil. Incidence of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors was 80% in rats fed ad libitum and 20% in those fed the calorie-restricted diets. Incidence of 1,2-dimethylhydrazine (DMH)-induced colon tumors was 100% in rats fed ad libitum and 53% in those whose caloric intake was restricted by 40%. The tumor yield (tumors per tumor-bearing rat) was significantly lower in rats on caloric restriction. In another series, rats were fed diets containing 5, 15 or 20% corn oil ad libitum or were fed calorie-restricted (by 25%) diets which provided 20 or 26.6% corn oil (therefore, the same absolute amount of fat was consumed in each of the pair-fed groups). Tumor incidence and tumor yield in the two calorie-restricted groups were similar to those seen in the rats fed 5% fat ad lititum; tumor burden (total g of tumor) was 45–65% lower in the calorie-restricted rats. The data suggest that caloric intake is a more stringent determinant of tumor growth than fat intake.

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  1. 1.

    Moreschi, C. (1909)Z Immunitätsforsch. 2, 651–673.

    Google Scholar 

  2. 2.

    Rous, P. (1910–11)Proc. Soc. Exp. Biol. Med. 8, 128–130.

    Google Scholar 

  3. 3.

    Bischoff, F., Long, M.L. and Maxwell, L.C. (1935)Am. J. Cancer 24, 549–553.

    CAS  Google Scholar 

  4. 4.

    Sivertsen, I., and Hastings, W.H. (1938)Minnesota Med. 21, 873–875.

    Google Scholar 

  5. 5.

    Tannenbaum, A. (1940)Am. J. Cancer 38, 335–350.

    CAS  Google Scholar 

  6. 6.

    Tannenbaum, A. (1942)Cancer Res. 2, 460–467.

    CAS  Google Scholar 

  7. 7.

    Tannenbaum, A. (1945)Cancer Res. 5, 609–615.

    CAS  Google Scholar 

  8. 8.

    Tannenbaum, A. (1945)Cancer Res. 5, 616–625.

    CAS  Google Scholar 

  9. 9.

    Lavik, P.S., and Baumann, C.A. (1943)Cancer Res. 3, 749–756.

    CAS  Google Scholar 

  10. 10.

    Kritchevsky, D., Weber, M.M., and Klurfeld, D.M. (1984)Cancer Res. 44, 3174–3177.

    PubMed  CAS  Google Scholar 

  11. 11.

    Pozharisski, K.M. (1973) inPathology of Tumours in Laboratory Animals (Turusov, V.S., ed.) Vol. I, Part 1, pp. 119–140, IARC, Lyon.

    Google Scholar 

  12. 12.

    Bernhart, F.W., and Tomarelli, R.M. (1966)J. Nutr. 89, 495–500.

    PubMed  CAS  Google Scholar 

  13. 13.

    Am. Inst. Nutr. Ad Hoc Committee on Standards for Nutritional Studies (1977)J. Nutr. 107, 1340–1348.

    Google Scholar 

  14. 14.

    Carroll, K.K., and Khor, H.T. (1971)Lipids, 6, 415–420.

    PubMed  CAS  Article  Google Scholar 

  15. 15.

    Carroll, K.K., and Khor, H.T. (1970)Cancer Res. 20, 2260–2264.

    Google Scholar 

  16. 16.

    McCay, C.M., Ellis, G.H., Barnes, L.L., Smith, C.A.H., and Sperling, G. (1939)J. Nutr. 18, 15–25.

    CAS  Google Scholar 

  17. 17.

    Carlson, A.J., and Hoelzel, F. (1946)J. Nutr. 31, 363–375.

    Google Scholar 

  18. 18.

    Ross, M.H., and Bras, G. (1971)J. Natl. Cancer Inst. 47, 1095–1113.

    PubMed  CAS  Google Scholar 

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Correspondence to David Kritchevsky.

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Kritchevsky, D., Weber, M.M., Buck, C.L. et al. Calories, fat and cancer. Lipids 21, 272–274 (1986). https://doi.org/10.1007/BF02536411

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  • Caloric Restriction
  • DMBA
  • Tumor Incidence
  • Restricted Diet
  • Final Body Weight