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Δ22-β-Muricholic acid in monoassociated rats and conventional ratsacid in monoassociated rats and conventional rats

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Lipids

Abstract

Bile acids were analyzed in the bile, small and large intestines, and feces of germ-free rats after a single inoculation with one of six intestinal bacteria that had been originally isolated from human feces.Bacteroides vulgatus andBifidobacterium longum preferentially deconjugated tauro-β-muricholic acid and taurocholic acid, respectively.Clostridium ramosum, Peptostreptococcus productus andLactobacillus gasseri deconjugated both bile acids, butEscherichia coli did not deconjugate either one. Rats inoculated with bacteria that deconjugated tauro-β-muricholic acid produced Δ22-β-Muricholic acid in the feces. In contrast, Δ22-cholic acid could not be detected in rats inoculated with bacteria that deconjugated taurocholic acid.

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Abbreviations

FT:

Fourier transform

GC/MS:

gas chromatography/mass spectrometry

HPLC:

high-performance liquid chromatography

INADEQUATE:

incredible natural abundance double-quantum transfer experiment

NMR:

nuclear magnetic resonance

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Authors and Affiliations

  1. Department of Bacteriology, Hyogo College of Medicine, 663, Nishinomiya, Japan

    Takayuki Kayahara & Toshihide Tamura

  2. Department of Internal Medicine, Hyogo College of Medicine, 663, Nishinomiya, Japan

    Yoshiki Amuro & Kazuya Higashino

  3. Diagnostics Division, Shionogi & Co., Ltd., 2-5-1, Mishima, 566, Settsu-shi, Osaka, Japan

    Hirotsune Igimi & Kiyoshisa Uchida

Authors
  1. Takayuki Kayahara
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  2. Toshihide Tamura
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  3. Yoshiki Amuro
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  4. Kazuya Higashino
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  5. Hirotsune Igimi
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  6. Kiyoshisa Uchida
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Kayahara, T., Tamura, T., Amuro, Y. et al. Δ22-β-Muricholic acid in monoassociated rats and conventional ratsacid in monoassociated rats and conventional rats. Lipids 29, 289–296 (1994). https://doi.org/10.1007/BF02536334

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  • DOI: https://doi.org/10.1007/BF02536334

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