Abstract
In the present study, changes in phospholipid compositions of liver microsomes, erythrocyte membranes, platelets, aorta, cardiac muscle and brain of rats fed olive oil were compared with those of rats fed sunflower oil. Four groups of rats starting at weaning were fed for four weeks a basal diet containing 5 or 25% olive oil or sunflower oil. We found that oleic acid was higher and linoleic acid was lower in membrane phospholipids of olive oil fed rats compared to sunflower oil fed rats. Polyunsaturated fatty acids of the n−3 series were markedly elevated in all tissues of rats on the olive oil diets relative to those on the sunflower oil diets. The results are consistent with a lower linoleic/linolenic acid ratio induced by the olive oil diets, suggesting a positive correlation between olive oil ingestion and n−3 polyunsaturated fatty acid levels in cell and tissue lipids. The study suggests that an adequate intake of olive oil may enhance the conversion of n−3 fatty acids.
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Abbreviations
- LDL:
-
low density lipoprotein
- O-5:
-
5% olive oil diet
- O-25:
-
25% olive oil diet
- PC:
-
phosphatidylcholine
- PE:
-
phosphatidylethanolamine
- PL:
-
phospholipid
- PUFA:
-
polyunsaturated fatty acids
- S-5:
-
5% sunflower oil diet
- S-25:
-
25% sunflower oil diet
- TXA2 :
-
thromboxane A2
References
Leaf, A., and Weber, P.C. (1988)N. Engl. J. Med. 318, 549–557.
Dyerberg, J. (1986)Nutr. Rev. 44, 125–134.
McLennan, P. (1993)Am. J. Clin. Nutr. 57, 207–212.
Connor, W.E., Neuringer, M., and Reisbick, S. (1991) inWorld Reviews in Nutrition and Dietetics (Simopoulos, A.P., Kifer, R.R., Martin, R.E., and Barlow, S.M., eds.) Vol. 66, pp. 118–131, Karger, Basel.
Anderson, G.J., Connor, W.E., Corliss, J.D., and Lin, D.S. (1989)J. Lipid Res. 30, 433–441.
Neuringer, M., Anderson, G.J., and Connor, W.E. (1988)Annu. Rev. Nutr. 8, 517–541.
Periago, J.L., Suarez, M.D., and Pita, M.L. (1990)J. Nutr. 120, 986–994.
Periago, J.L., Pita, M.L., Sanchez del Castillo, M.A., Caamaño, G., and Suarez, M.D. (1989)Lipids 24, 383–388.
Abbey, M., Belling, G.B., Noakes, M., Hirata, F., and Nestel, P. (1993)Am. J. Clin. Nutr. 57, 391–398.
Popp-Snijders, C., Schouten, J.A., van Blitterwijk, W.J., and van der Veen, E.A. (1986)Biochim. Biophys. Acta 854, 31–37.
Ballabriga, A., and Martinez, M. (1976)Acta Paediatr. Scand. 65, 705–709.
Spector, A.A., and Yorek, M.A. (1985)J. Lipid Res. 26, 1015–1035.
Rao, C.V., Zang, E., and Reddy, B.S. (1993)Lipids 28, 441–447.
Dolocek, T.A., and Grandits, G. (1991) inWorld Reviews in Nutrition and Dietetics (Simopoulos, A.P., Kifer, R.R., Martin, R.E., and Barlow, S.M., eds.) Vol. 66, pp. 205–217, Karger, Basel.
Parthasarathy, S., Khoo, J.C., Miller, E., Barnett, J., Witztum, J.L., and Steinberg, D. (1990)Proc. Natl. Acad. Sci. USA 87, 3894–3898.
Grundy, S.M., and Denke, M.A. (1990)J. Lipid Res. 31, 1149–1171.
Ferro-Luzzi, A., Strazzullo, P., and Scaccini, C. (1984)Am. J. Clin. Nutr. 40, 1027–1037.
Mattson, F.H., and Grundy, S.M. (1985)J. Lipid Res. 26, 194–202.
Grundy, S.M. (1986)N. Engl. J. Med. 314, 745–748.
Masi, I., Giani, E., Galli, C., Tremoli, E., and Sirtori, C.R. (1986)Ann. Nutr. Metab. 30, 366–372.
Sirtori, C.R., Tremoli, E., Gatti, E., Montavari, G., and Sirtori, M. (1986)Am. J. Clin. Nutr. 44, 635–642.
Navarro, M.D., Hortelano, P., Periago, J.L., and Pita, M.L. (1992)Arteriosclerosis and Thrombosis 12, 830–835.
Ilar's Committee on Laboratory Animals' Diets (1979)Nutr Abs. Rev. 49, 413–419.
Hashimoto, Y., Naito, C.H., Kume, S., Kato, H., Watanabe, T., Kawamura, M., Teramoto, T., and Oka, H. (1985)Biochim. Biophys. Acta 841, 283–291.
Hanahan, D.H., and Ekholm, J.E. (1974)Methods Enzymol. 31, 168–172.
Philipp, B.W., and Shapiro, D.J. (1979)J. Lipid Res. 20, 588–593.
Folch, J., Lees, M., and Stanley, G.S.H. (1957)J. Biol. Chem. 226, 497–509.
Skipsi, V.P., and Barclay, M. (1969)Methods Enzymol. 14, 548–550.
Vitiello, F., and Zanetta, J.P. (1978)J. Chromatogr. 166, 637–640.
Morrison, W.R., and Smith, L.M. (1964)J. Lipid Res. 5, 600–607.
Needleman, S.W., Spector, A.A., and Hoak, J.C. (1982)Prostaglandins 24, 607–622.
Weiner, T.W., and Sprecher, H. (1985)J. Biol. Chem. 260, 6032–6038.
Anding, R.H., and Hwang, D.H. (1986)Lipids 21, 697–701.
Terao, J., Nagao, A., Suzuki, H., and Yamakazi, M. (1991)J. Agric. Food Chem. 39, 1477–1481.
Brenner, R.R., and Peluffo, R.O. (1966)J. Biol. Chem. 241, 5213–5216.
Zevenbergen, J.L., and Houtsmuller, U.M.T. (1989)Biochim. Biophys. Acta 1002, 312–323.
Horrobin, H. (1993)Am. J. Clin. Nutr. 57, 732S-737S.
Gonzalez, J., Periago, J.L., Gil, A., Cabré, E., Abad-Lacruz, A., Gassull, M.A., and Sánchez-Medina, F. (1992)Metabolism 41, 954–960.
Simopoulos, A.P. (1991)Am. J. Clin. Nutr. 54, 438–463.
Uauy, R.D., Birch, D.G., Birch, E.E., Tyson, J.E., and Hoffman, D.R. (1990)Pediatr. Res. 28, 485–492.
Martinez, M., Ballabriga, A., and Gil-Gibernau, J.J. (1988)J. Neurosci Res. 20, 484–490.
Yamamoto, N., Saitoh, M., Moriuchi, A., Nomura, M., and Okuyama, H. (1987)J. Lipid Res. 28, 144–151.
Karmali, R.A. (1989) inDietary n−3 and n−6 Fatty Acids: Biological Effects and Nutritional Essentiality (Galli, C., and Simopoulos, A.P., eds.) pp. 351–359, Plenum Press, New York.
Galli, C., and Butrum, R. (1991) inWorld Reviews in Nutrition and Dietetics (Simopoulos, A.P., Kifer, R.R., Martin, R.E., and Barlow, S.M., eds.) Vol. 66, pp. 446–461, Karger, Basel.
Goodnight, S.H., Harris, W.S., Connor, W.E., and Illingworth, D.R. (1982)Arteriosclerosis.2, 87–113.
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Navarro, M.D., Periago, J.L., Pita, M.L. et al. The n−3 polyunsaturated fatty acid levels in rat tissue lipids increase in response to dietary olive oil relative to sunflower oil. Lipids 29, 845–849 (1994). https://doi.org/10.1007/BF02536252
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DOI: https://doi.org/10.1007/BF02536252