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Effects of estrogen-induced hyperlipidemia on the erythrocyte membrane in chicks

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Lipids

Abstract

The effects of estrogen-induced hyperlipidemia on plasma lipid peroxidation, fatty acid composition and osmotic fragility of erythrocytes in chickens were studied. Young male chickens implanted with estrogen for three wk developed a marked hyperlipidemia. Plasma levels of triglyceride, cholesterol and phospholipid were elevated 68-, four- and 24-fold, respectively, over controls. There was also a two-fold increase in plasma lipid peroxidation measured by the thiobarbituric acid test. Vitamin E supplement (1,000 IU/kg diet) reduced the plasma lipid peroxidation to the control level, but had no effect on the plasma lipid content. Estrogen-induced hyperlipidemia resulted in changes in the fatty acid composition of membrane lipids of erythrocytes. The major changes were an increase in oleic acid from 10.0% to 14.2% and a decrease in linoleic acid from 31.3% to 26.0%. The erytrocytes with an altered membrane fatty acid composition were found to have an increased osmotic fragility. It was apparent that there was a direct correlation between the oleic acid content and the osmotic fragility of erythrocytes.

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Abbreviations

TBARS:

thiobarbituric acid reacting substance

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Authors and Affiliations

  1. Harlan E. Moore Heart Research Foundation, 503 South Sixth Street, 61820, Champaign, IL

    B. H. Simon Cho, Terrance L. Smith, Jeong R. Park & Fred A. Kummerow

  2. Department of Food Science, University of Illinois, 1208 West Pennsylvania Avenue, 61801, Urbana, IL

    B. H. Simon Cho, Terrance L. Smith, Jeong R. Park & Fred A. Kummerow

Authors
  1. B. H. Simon Cho
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  2. Terrance L. Smith
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  3. Jeong R. Park
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  4. Fred A. Kummerow
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Simon Cho, B.H., Smith, T.L., Park, J.R. et al. Effects of estrogen-induced hyperlipidemia on the erythrocyte membrane in chicks. Lipids 23, 853–856 (1988). https://doi.org/10.1007/BF02536204

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  • DOI: https://doi.org/10.1007/BF02536204

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