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Increments of dietary linoleate raise liver arachidonate, but markedly reduce heart n−6 and n−3 fatty acids in the rat

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Lipids

Abstract

Four diets containing 20% of energy (en%) as fat and with linoleic acid contents of 1.9, 3.1, 7.7 and 10.1 en%, respectively, were fed to one-month-old male rats for three months. The fatty acid profiles and the levels of the major n−6 and n−3 fatty acids in the lipids of plasma, liver, heart and kidney were measured. We found that with increasing concentrations of 18∶2n−6 in the diet, linoleic acid rose in plasma and in all organs, but long-chain n−6 and n−3 fatty acids responded differently. In liver, arachidonic acid increased and n−3 fatty acids were not significantly affected; in heart, both arachidonic and docosahexaenoic acids were progressively reduced; and in kidney, there was no change of n−6 and n−3. The results indicate that incremental changes in dietary, linoleate affect the levels of polyunsaturated fatty acids in liver and extrahepatic organs differently.

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Abbreviations

AA:

arachidonic acid

ANOVA:

analysis of variance

CE:

cholesteryl esters

DHA:

docosahexaenoic acid

EFA:

essential fatty acids

en%:

percent energy

EPA:

eicosapentaenoic acid

FA:

fatty acids

HUFA:

highly unsaturated fatty acids

LA:

linoleic acid

PL:

phospholipids

PUFA:

polyunsaturated fatty acids

TG:

triglycerides

GOT:

glutamic-oxalacetic transaminase

LDH:

lactic dehydrogenase

GPT:

glutamic-pyruvic transaminase

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Authors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy

    Franca Marangoni, Cristina Mosconi, Gerardina Galella & Claudio Galli

Authors
  1. Franca Marangoni
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  2. Cristina Mosconi
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  3. Gerardina Galella
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  4. Claudio Galli
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Marangoni, F., Mosconi, C., Galella, G. et al. Increments of dietary linoleate raise liver arachidonate, but markedly reduce heart n−6 and n−3 fatty acids in the rat. Lipids 27, 624–628 (1992). https://doi.org/10.1007/BF02536121

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  • DOI: https://doi.org/10.1007/BF02536121

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