Skip to main content
SpringerLink
Log in

Effects of various dietary fats on cardiolipin acyl composition during ontogeny of mice

  • Article
  • Published:
Lipids

Abstract

Cardiolipin (CL) is a unique mitochondrial phospholipid, containing up to 85 wt% 18∶2n−6 in mammals. The influence of maternal dietary fatty acids on the acyl composition of offspring CL has not been examined previously. Adult female mice were thus fed diets rich in 18∶1n−9 (olive oil), 18∶2n−6 (safflower oil), 18∶3n−3 (linseed oil) or 20∶5n−3 and 22∶6n−3 (fish oil/safflower, 9∶1, w/w), for a five month period, encompassing two breeding cycles. Offspring from the second breeding cycle were then fed these diets. The acyl composition of CL, phosphatidylcholine and phosphatidylethanolamine from liver and heart was evaluated from mice killed 3, 18 and 42 days after parturition. The primary nutrient sources at these three time points were transplacental nutrients, breast milk and the diet, respectively. Maternal diet was found to influence the acyl composition of CLvia both placental transfer of fatty acids and breast milk. Fish oil feeding resulted in replacement of a substantial portion of 18∶2n−6 with 22∶6n−3; after 42 days, the area% of 18∶2n−6 in heart CL was reduced from 62% in safflower oil fed mice to 12%. In comparison to fish oil feeding, linseed oil feeding resulted in a much lower accumulation of 22∶6n−3. Olive oil feeding resulted in substantial replacement of 18∶2n−6 with 18∶1n−9 (18∶2n−6 was reduced from 62% to 31%). Physiologically, these findings are relevant because changes in CL acyl composition may influence the activity of associated inner mitochondrial membrane enzymes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ANOVA:

analysis of variance

aPL:

antiphospholipid antibodies

CL:

cardiolipin

FAME:

fatty acid methyl ester

HPTLC:

high-performance thin-layer chromatography

PC:

phosphatidylcholine

PE:

phosphatidylethanolamine

References

  1. Hostetler, K.Y. (1982) inPhospholipids (Hawthorne, J.N., and Ansell, G.B. eds.), pp. 215–261, Elsevier Biomedical Press, Amsterdam.

    Google Scholar 

  2. Schlame, M., and Rüstow, B. (1990)Biochem. J. 272, 589–595.

    PubMed  CAS  Google Scholar 

  3. Wolff, R.L., and Entressangles, B. (1991)Biochem. Biophys. Acta 1082, 136–142.

    PubMed  CAS  Google Scholar 

  4. Vik, S.B., Georgevich, G., and Capaldi, R.A. (1981)Proc. Natl. Acad. Sci. USA 78, 1456–1460.

    Article  PubMed  CAS  Google Scholar 

  5. Brady, L.J., and Brady, P.S. (1987)Biochem. Pharmacol. 36, 3419–3423.

    Article  PubMed  CAS  Google Scholar 

  6. Cheneval, D., and Carafoli, E. (1988)Eur. J. Biochem. 171, 1–9.

    Article  PubMed  CAS  Google Scholar 

  7. Brandt, M.A., and Powers, L.S. (1991)Arch. Biochem. Biophys. 290, 14–20.

    Article  PubMed  CAS  Google Scholar 

  8. Hübner, W., Mantsch, H.H., and Kates, M. (1991)Biochim. Biophys. Acta 1066, 166–174.

    Article  PubMed  Google Scholar 

  9. Paradies, G., Ruggiero, F.M., Gadaleta, M.N., and Quagliariello, E. (1992)Biochim. Biophys. Acta 1103, 324–326.

    Article  PubMed  CAS  Google Scholar 

  10. Abramovitch, D.A., Marsh, D., and Powell, G.L. (1990)Biochim. Biophys. Acta 1020, 34–42.

    Article  PubMed  CAS  Google Scholar 

  11. Robinson, N.C., Zborowski, J., and Talbert, L.H. (1990)Biochemistry 29, 8962–8969.

    Article  PubMed  CAS  Google Scholar 

  12. Spooner, P.J.R., and Watts, A. (1991)Biochemistry 30, 3871–3879.

    Article  PubMed  CAS  Google Scholar 

  13. Yamaoka, S., Urade, R., and Kito, M. (1988)J. Nutr. 118, 290–296.

    PubMed  CAS  Google Scholar 

  14. Croset, M., and Kinsella, J.E. (1989)Ann. Nutr. Metab. 33, 125–142.

    PubMed  CAS  Google Scholar 

  15. Yamaoka, S., Urade, R., and Kito, M. (1990)J. Nutr. 120, 415–421.

    PubMed  CAS  Google Scholar 

  16. Schlame, M., Horvath, I., Torok, Z., Horvath, L.I., and Vigh, L. (1990)Biochim. Biophys. Acta 1045, 1–8.

    PubMed  CAS  Google Scholar 

  17. Schlame, M., Beyer, K., Hartl-Hayer, M., and Klingenberg, M. (1991)Eur. J. Biochem. 199, 459–466.

    Article  PubMed  CAS  Google Scholar 

  18. Yamaoka-Koseki, S., Urade, R., and Kito, M. (1991)J. Nutr. 121, 956–958.

    PubMed  CAS  Google Scholar 

  19. Berger, A., German, J.B., and Gershwin, M.E. (1992)J. Autoimmunity 5, 229–241.

    Article  CAS  Google Scholar 

  20. Wolff, R.L. (1988)Reprod. Nutr. Dev. 28, 1489–1507.

    PubMed  CAS  Google Scholar 

  21. Berger, A., and German, J.B. (1990)Lipids 25, 473–480.

    PubMed  CAS  Google Scholar 

  22. Høy, C.E., and Hølmer, G. (1990)Lipids 25, 455–459.

    PubMed  Google Scholar 

  23. Javouhey, A., Rocquelin, G., Rochette, L., and Juanéda, P. (1990)Nutr. Res. 10, 291–301.

    Article  CAS  Google Scholar 

  24. Astorg, P.-O., and Chevalier, J. (1991)Nutr. Res. 11, 71–77.

    Article  CAS  Google Scholar 

  25. American Institute of Nutrition (1980)J. Nutr. 110,1726.

    Google Scholar 

  26. Burton, G.W., Webb, A., and Ingold, K.U. (1985)Lipids 20, 29–39.

    Article  PubMed  CAS  Google Scholar 

  27. Holub, B.J., and Skeaff, C.M. (1987)Methods Enzymol. 141, 234–244.

    PubMed  CAS  Google Scholar 

  28. Lepage, G., Levy, E., Ronco, N., Smith, L., Galéano, N., and Roy, C.C. (1989)J. Lipid Res. 30,1483–1490.

    PubMed  CAS  Google Scholar 

  29. Zar, J.H. (1984)Biostatistical Analysis, Prentice-Hall, Englewood Cliffs.

    Google Scholar 

  30. Winkler, L., Buanga, N.-F., and Goetze, E. (1971)Biochim. Biophys. Acta 231, 535–536.

    PubMed  CAS  Google Scholar 

  31. Kramer, J.K.G. (1980)Lipids 15, 651–660.

    Article  PubMed  CAS  Google Scholar 

  32. Innis, S.M., and Clandinin, M.T. (1981)Biochem. J. 193, 155–167.

    PubMed  CAS  Google Scholar 

  33. Palmer, J.W., Schmid, P.C., Pfeiffer, D.R., and Schmid, H.H.O. (1981)Arch. Biochem. Biophys. 211, 674–682.

    Article  PubMed  CAS  Google Scholar 

  34. Keränen, A., Kankare, P., and Hallman, M. (1982)Lipids 17, 155–159.

    Article  PubMed  Google Scholar 

  35. Wolff, R.L., Combe, N.A., and Entressangles, B. (1984)Rev. Fr. Corps. Gras. 31, 161–170.

    CAS  Google Scholar 

  36. Bruce, Å. (1974)J. Lipid Res. 15, 109–113.

    PubMed  CAS  Google Scholar 

  37. Wolf, W.J., Rex, K.A., Geshi, E., and Sordahl, L.A. (1991)Am. J. Physiol. 261, H1-H8.

    PubMed  CAS  Google Scholar 

  38. Charnock, J.S., Abeywardena, M.Y., and McLennan, P.L. (1986)Ann. Nutr. Metab. 30, 393–406.

    Article  PubMed  CAS  Google Scholar 

  39. Swanson, J.E., and Kinsella, J.E. (1986)J. Nutr. 116, 514–523.

    PubMed  CAS  Google Scholar 

  40. Gudbjarnason, S., Ośkardóttir, G., Boell, B., and Hallgrímsson, J. (1978)Adv. Cardiol. 25, 130–144.

    PubMed  CAS  Google Scholar 

  41. Lands, W.E., Morris, A., and Libelt, B. (1990)Lipids 25, 505–516.

    PubMed  CAS  Google Scholar 

  42. Mohammed, B.S., Hagve, T.-A., and Sprecher, H. (1990)Lipids 25, 854–858.

    PubMed  CAS  Google Scholar 

  43. Stremmel, W. (1988)J. Clin. Invest. 81, 844–852.

    PubMed  CAS  Google Scholar 

  44. Sprecher, H. (1977) inPolyunsaturated Fatty Acids (Kunau, W.-H., and Holman, R.T., eds.), pp. 1–18, American Oil Chemists' Society, Champaign.

    Google Scholar 

  45. Kameyama, Y., Yoshioka, S., Imai, A., and Nozawa, Y. (1983)Biochim. Biophys. Acta 752, 244–250.

    PubMed  CAS  Google Scholar 

  46. Schalkwijk, C.G., Märki, F., and van den Bosch, H. (1990)Biochim. Biophys. Acta 1044, 139–146.

    PubMed  CAS  Google Scholar 

  47. Gavino, G.R., and Gavino, V.C. (1991)Lipids 26, 266–270.

    PubMed  CAS  Google Scholar 

  48. Voss, A., Reinhart, M., Sankarappa, S., and Sprecher, H. (1991)J. Biol. Chem. 266, 1995–20000.

    Google Scholar 

  49. Høy, C.E., Hølmer, G., Kaur, N., Byrjalsen, I., and Kirstein, D. (1983)Lipids 18, 760–771.

    PubMed  Google Scholar 

  50. Mandon, E.C., de Gómez Dumm, I.N.T., and Brenner, R.R. (1986)Arch. Latinoam. Nutr. 36, 401–414.

    PubMed  CAS  Google Scholar 

  51. Sprecher, H., Voss, A.C., Careaga, M., and Hadjiagapiou, C. (1987) inProceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids (Lands, W.E.M., ed.) pp. 154–168, American Oil Chemists' Society, Champaign.

    Google Scholar 

  52. Cook, H.W., Byers, D.M., Palmer, F.B.S.C., Spence, M.W., Rakoff, H., Duval, S.M., and Emken, E.A. (1991)J. Lipid Res. 32, 1265–1273.

    PubMed  CAS  Google Scholar 

  53. Schlame, M., and Otten, D. (1991)Anal. Biochem. 195, 290–295.

    Article  PubMed  CAS  Google Scholar 

  54. Landriscina, C., Megli, F.M., and Quagliariello, E. (1976)Lipids 11, 61–66.

    Article  PubMed  CAS  Google Scholar 

  55. Dyer, J.R., and Greenwood, C.E. (1991)J. Nutr. 121, 1548–1553.

    PubMed  CAS  Google Scholar 

  56. Rüstow, B., Schlame, M., Rabe, H., Reichmann, G., and Kunze, D. (1989)Biochim. Biophys. Acta 1002, 261–263.

    PubMed  Google Scholar 

  57. Stuhne-Sekalec, L., and Stanacev, N.Z. (1990)Biochem. Cell. Biol. 68, 922–935.

    Article  PubMed  CAS  Google Scholar 

  58. Blomstrand, R., and Svensson, L. (1974)Lipids, 9, 771–780.

    Article  PubMed  CAS  Google Scholar 

  59. Hsu, C.M.S., and Kummerow, F.A. (1977)Lipids 12, 486–494.

    PubMed  CAS  Google Scholar 

  60. Renner, R., Innis, S.M., and Clandinin, M.T. (1979)J. Nutr. 109, 378–387.

    PubMed  CAS  Google Scholar 

  61. Berger, A., and German, J.B. (1991)Biochim. Biophys. Acta 1085, 371–376.

    PubMed  CAS  Google Scholar 

  62. Blomstrand, R., and Svensson, L. (1983)Lipids 18, 151–170.

    PubMed  CAS  Google Scholar 

  63. Christon, R., Fernandez, Y., Cambon, G.C., Periquet, A., Deltour, P., Leger, C.L., and Mitjavila, S. (1988)J. Nutr. 118, 1311–1318.

    PubMed  CAS  Google Scholar 

  64. Nalbone, G., Termine, E., Leonardi, J., Portugal, H., Lechene, P., Calaf, R., Lafont, R., and Lafont, H. (1988)J. Nutr. 118, 809–817.

    PubMed  CAS  Google Scholar 

  65. McNeil, H.P., Chesterman, C.N., and Krilis, S.A. (1991)Adv. Immunol. 49, 193–280.

    Article  PubMed  CAS  Google Scholar 

  66. Blank, M., Cohen, J., Toder, V., and Shoenfeld, Y. (1991)Proc. Natl. Acad. Sci. USA 88, 3069–3073.

    Article  PubMed  CAS  Google Scholar 

  67. Levy, R.A., Gharavi, A.E., Sammaritano, L.R., Habina, L., and Lockshin, M.D. (1990)J. Clin. Immunol. 10,141–145.

    Article  PubMed  CAS  Google Scholar 

  68. Qamar, T., Gharavi, A.E., Levy, R.A., and Lockshin, M.D. (1990)J. Clin. Immunol. 10, 200–203.

    Article  PubMed  CAS  Google Scholar 

  69. Narabayashi, H., Takeshige, K., and Minakami, S. (1982)Biochem. J. 202, 97–105.

    PubMed  CAS  Google Scholar 

  70. Parinandi, N.L., Weis, B.K., and Schmid, H.H.O. (1987)FASEB J. 2, A1790.

    Google Scholar 

  71. Soussi, B., Bylund-Fellenius, A.-C., Scherstén, T., and Ångstrom, J. (1990)Biochem. J. 265, 227–232.

    PubMed  CAS  Google Scholar 

  72. Radi, R., Turrens, J.F., and Freeman, B.A. (1991)Arch. Biochem. Biophys. 288, 118–125.

    Article  PubMed  CAS  Google Scholar 

  73. Malis, C.D., Weber, P.C., Leaf, A., and Bonventre, J.V. (1990)Proc. Natl. Acad. Sci. USA 87, 8845–8849.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Food Science and Technology, University of California at Davis, 95616, Davis, California

    Alvin Berger & J. Bruce German

  2. Division of Rheumatology and Immunology, University of California at Davis, 95616, Davis, California

    M. E. Gershwin

Authors
  1. Alvin Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. E. Gershwin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Bruce German
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was presented in part as an Honored Student Award paper at the 82nd Annual AOCS Meeting, Chicago, IL, May 1991.

About this article

Cite this article

Berger, A., Gershwin, M.E. & German, J.B. Effects of various dietary fats on cardiolipin acyl composition during ontogeny of mice. Lipids 27, 605–612 (1992). https://doi.org/10.1007/BF02536118

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02536118

Keywords

Search

Navigation