Skip to main content
SpringerLink
Log in

Diabetes increases excretion of urinary malonaldehyde conjugates in rats

  • Article
  • Published:
Lipids

Abstract

The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabetic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performance liquid chromatography of urine samples revealed that five of the six fractions previously found to be increased in vitamin E deficiency [Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124–128] were also significantly increased in streptozotocin-induced diabetes. The data suggest that a high level of oxidative stress is induced by uncontrolled diabetes in rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

GHb:

glycated hemoglobin

HPLC:

high-performance liquid chromatography

MDA:

malonaldehyde

TBA:

thiobarbituric acid

TBARS:

thiobarbituric acid reactive substances

References

  1. Sevanian, A., and Hochstein, P. (1985)Ann. Rev. Nutr. 5, 365–390.

    Article  CAS  Google Scholar 

  2. Pryor, W. (1985) inXenobiotic Metabolism: Nutrition Effects (Finley, J.W., and Schwass, D.E., eds.) pp. 77–96, American Chemical Society, Washington, D.C.

    Google Scholar 

  3. Kwon, T.W., Menzel, D.B., and Olcott, H.S. (1965)J. Food Sci. 30, 808–813.

    Article  CAS  Google Scholar 

  4. Draper, H.H., Hadley, N., Lissemore, L., Laing, N.M., and Cole, R.P. (1988)Lipids 23, 626–628.

    Article  PubMed  CAS  Google Scholar 

  5. Lee, H.-S., and Csallany, A.S. (1987)Lipids 22, 104–107.

    Article  PubMed  CAS  Google Scholar 

  6. Crawford, D.L., Yu, T.C., and Sinnhuber, R.O. (1966)J. Agric. Food Chem. 14, 182–184.

    Article  CAS  Google Scholar 

  7. Chio, K.S., and Tappel, A.L. (1969)Biochemistry 8, 2821–2827.

    Article  PubMed  CAS  Google Scholar 

  8. Draper, H.H., Polensek, L., Hadley, M., and McGirr, L.G. (1984)Lipids 19, 836–843.

    Article  PubMed  CAS  Google Scholar 

  9. Ekström, T., Stahl, A., Sigvardsson, K., and Hogberg, J. (1986)Acta Pharmacol. Toxicol. 58, 289–296.

    Article  Google Scholar 

  10. Jain, S.K. (1989)J. Biol. Chem. 264, 21340–21345.

    PubMed  CAS  Google Scholar 

  11. Jain, S.K., Levine, S.N., Duett, J., and Hollier, B. (1990)Metabolism 39, 971–975.

    Article  PubMed  CAS  Google Scholar 

  12. Karpen, C.W., Pritchard, Jr., K.A., Arnold, J.H., Cornwell, D.G., and Panganamala, R.V. (1982)Diabetes 31, 947–951.

    CAS  Google Scholar 

  13. Noberasco, G., Odetti, P., Boeri, D., Maiello, M., and Adezati, L. (1991)Biomed. & Pharmacother 45, 193–196.

    Article  CAS  Google Scholar 

  14. Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992)Lipids 27, 124–128.

    PubMed  CAS  Google Scholar 

  15. Tarladgis, B.G., Pearson, A.M., and Dugan Jr., L.R. (1964)J. Sci. Food Agric. 15, 602–607.

    Article  Google Scholar 

  16. Csallany, A.S., Guan, M.D., Manwaring, J.D., and Addis, P.B. (1984)Anal. Biochem. 142, 277–283.

    Article  PubMed  CAS  Google Scholar 

  17. Bunn, H. (1981)Amer. J. Med. 70, 325–330.

    Article  PubMed  CAS  Google Scholar 

  18. Gabbay, K., Hasty, K., Breslow, J., Ellison, R., Bunn, H., and Gallop, P. (1977)J. Clin. Endocrinol. Metab. 44, 859–865.

    Article  PubMed  CAS  Google Scholar 

  19. Koenig, R., Peterson, C., Kilo, C., Cerami, A., and Williamson, J. (1976)Diabetes 25, 230–232.

    PubMed  CAS  Google Scholar 

  20. Seyer-Hansen, K. (1976)Clin. Sci. Molec. Med. 51, 551–555.

    CAS  Google Scholar 

  21. Seyer-Hansen, K. (1977)Diabetologia 13, 141–143.

    Article  PubMed  CAS  Google Scholar 

  22. Hjelle, J.J., and Petersen, D.R. (1983)Toxicol. Appl. Pharmacol. 70, 57–66.

    Article  PubMed  CAS  Google Scholar 

  23. Siu, G.M., and Draper, H.H. (1982)Lipids 17, 349–355.

    PubMed  CAS  Google Scholar 

  24. Hunt, J.V., Dean, R.T., and Wolff, S.P. (1988)Biochem. J. 256, 205–212.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, 55108, St. Paul, MN

    Daniel D. Gallaher, A. Saari Csallany, Don W. Shoeman & Judith M. Olson

Authors
  1. Daniel D. Gallaher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Saari Csallany
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Don W. Shoeman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Judith M. Olson
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Paper No. 20,002 of the scientific series of the Minnesota Agricultural Experiment Station on research conducted under the Minnesota Experiment Station projects Nos. 18-058 and 18-085.

About this article

Cite this article

Gallaher, D.D., Csallany, A.S., Shoeman, D.W. et al. Diabetes increases excretion of urinary malonaldehyde conjugates in rats. Lipids 28, 663–666 (1993). https://doi.org/10.1007/BF02536063

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02536063

Keywords

Search

Navigation