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Lipids

, Volume 30, Issue 4, pp 357–359 | Cite as

Induction of geranyl pyrophosphate pyrophosphatase activity by cholesterol-suppressive isoprenoids

  • Gary L. Case
  • Lei He
  • Huanbiao Mo
  • Charles E. Elson
Communication

Abstract

Diets supplemented (1 mmol/kg) with thymol, carvacrol, and β-ionone significantly decreased the serum cholesterol levels of cockerels. These mevalonate-derived end products of plant secondary metabolism (isoprenoids) had no impact on two cytosolic prenyl alcohol (and ethanol) dehydrogenase activities; each treatment increased microsomal geranyl pyrophosphate pyrophosphatase activity by greater than twofold. The structural diversity of the isoprenoids which suppress cholesterol synthesis may be reconciled by their ability to increase pyrophosphatase activity, thus leading to the production of the endogenous, post-transcriptional regulator of 3-hydroxy-3-methyglutaryl coenzyme A reductase activity.

Keywords

Isoprenoids Thymol Serum Cholesterol Level Geraniol Carvacrol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

HMG-CoA

3-hydroxy-3-methylglutaryl CoA

PP

pyrophosphate

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Copyright information

© American Oil Chemists’ Society 1995

Authors and Affiliations

  • Gary L. Case
    • 1
  • Lei He
    • 1
  • Huanbiao Mo
    • 1
  • Charles E. Elson
    • 1
  1. 1.Department of Nutritional SciencesUniversity of WisconsinMadison

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